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EC number: 904-304-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to EEC Method C.4-E and O.E.C.D. Testing Guideline No. 301D Closed Bottle Test with GLP compliance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-E (Determination of the "Ready" Biodegradability - Closed Bottle Test)
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (1E)-1,3-dichloroprop-1-ene; 1,2-dichloropropane
- EC Number:
- 904-304-2
- Molecular formula:
- Multi-constituent: C3H4Cl2 and C3H6Cl2
- IUPAC Name:
- (1E)-1,3-dichloroprop-1-ene; 1,2-dichloropropane
- Reference substance name:
- Crude 1,3-dichloropropene
- IUPAC Name:
- Crude 1,3-dichloropropene
- Details on test material:
- As per IUCLID5 Sections 1.1. - 1.4.
Constituent 1
Constituent 2
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- The activated sludge was collected on the day of the test from Thorndon Sewage Treatment Works (Suffolk, UK), a trickling-filter plant which treats predominantly domestic waste. It was maintained under aerobic conditions in the laboratory and immediately before use the sludge sample filtered through glass wool and the filtrate used as the inoculum for the test (1 mL filtrate/litre test medium).
- Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 2 mg/L
- Based on:
- test mat.
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- Two groups of eighteen Biological Oxygen Demand (BOD) bottles (standard bottles, 227 mL) were filled with inoculated
Mineral Salts Medium alone, and with inoculated Mineral Salts Medium and sodium benzoate (2 mg/L) the positive control. Care was taken to avoid the introduction of air bubbles during filling. A third group of BOD bottles (modified with an injection port) were filled with inoculated Mineral Salts Medium and were sealed before the test substance was injected directly into the bottles. A fourth group of four modified bottles was included to determine whether the test substance was inhibitory to the microbial activity of the inoculum during seven days of incubation, contained inoculated Mineral Salts Medium, sodium benzoate and the test substance. The concentrations of dissolved oxygen (DO), temperatures and pH of the contents of duplicate vessels from each group were measured, using a YSI dissolved oxygen meter fitted with a self-stirring DO/temperature bottle probe and a pH meter, at the start of the test after 5, 7, 11, 14, 18, 21, 25 and 28 days at 22 ± 2°C.
Results and discussion
- Preliminary study:
- In a preliminary solubility trial, Crude 1,3-Dichloropropene was not found to be sufficiently soluble in ultrapure water to allow the preparation of an aqueous stock solution. Test concentrations (nominally 2 mg/L) were established by injecting the test substance (0.6 μl based on density) directly to sealed vessels pre-filled with inoculated media.
- Test performance:
- The temperatures of the contents of the BOD bottles and incubator ranged from 21.1 to 22.9°C and 21.2 to 22.6°C, respectively during the test, and the pH of the mixtures ranged from 7.3 to 8.1.
% Degradation
- Parameter:
- % degradation (O2 consumption)
- Value:
- 2
- Sampling time:
- 28 d
- Details on results:
- Oxygen consumption in bottles containing Crude 1,3-Dichloropropene alone was negligible (at most, 0.09 mgO2/mg or 2% of its COD). Sodium benzoate the positive control had been degraded to 70% of its ThOD (1.67 mgO2/mg) after 14 days of incubation. In the presence of Crude 1,3-Dichloropropene, sodium benzoate had been degraded by 32% after seven days of contact.
BOD5 / COD results
- Results with reference substance:
- Sodium benzoate had been degraded by approximately 70% after 14 days of contact.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Crude 1,3-Dichloropropene was not considered to be readily degradable under the conditions of this test. However, Crude 1,3-dichloropropene at 2 mg/L reduced the biodegradation of the positive control, sodium benzoate approximately 2-fold during seven days of contact suggesting a potential for the inhibition of sludge mediated biodegradation.
- Executive summary:
Crude 1,3 -dichloropropene was evaluated biodegradation potential in an EEC Method C.4 -e and O.E.C.D. Testing Guideline 301D Closed Bottle Test with GLP compliance. Crude 1,3-Dichloropropene was not considered to be readily degradable under the conditions of this test. However, Crude 1,3-dichloropropene at 2 mg/L reduced the biodegradation of the positive control, sodium benzoate approximately 2-fold during seven days of contact suggesting a potential for the inhibition of sludge mediated biodegradation.
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