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EC number: 457-320-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
EC#457-320-2 has been tested in reproduction and developmental toxicity screening study in rats, conducted in accordance with GLP and OECD TG 421. Doses used were 0, 100, 300 and 1000 mg/kg bw/day. Some parental animals in the top dose group showed signs of behavioural/CNS effects, such as intermittent tremors, repetitive movements of mouth and jaws, and excessive pawing and licking of the cage. The female top dose group also had an increase mean liver weight compared to the control group. The NOAEL for general parental toxicity was therefore concluded to be 300 mg/kg bw/day. However, there were no effects on reproductive indices, and the NOAEL for reproduction toxicity was concluded to be 1,000 mg/kg bw/day.
Short description of key information:
The NOAEL for reproduction toxicity is 1000 mg/kg bw/day
Effects on developmental toxicity
Description of key information
The NOAEL for developmental toxicity is 1000 mg/kg bw/day
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
Additional information
EC#457-320-2 has been tested in reproduction and developmental toxicity screening study in rats, conducted in accordance with GLP and OECD TG 421. Doses used were 0, 100, 300 and 1000 mg/kg bw/day. Some parental animals in the top dose group showed signs of behavioural/CNS effects, such as intermittent tremors, repetitive movements of mouth and jaws, and excessive pawing and licking of the cage. The female top dose group also had an increase mean liver weight compared to the control group. The NOAEL for general parental toxicity was therefore concluded to be 300 mg/kg bw/day. However, there were no effects on any neonatal parameters assessed, and the NOAEL for developmental toxicity was concluded to be 1,000 mg/kg bw/day.
Justification for classification or non-classification
EC#457-320-2 has been tested in reproduction and developmental toxicity screening study in rats, conducted in accordance with GLP and OECD TG 421. Doses used were 0, 100, 300 and 1000 mg/kg bw/day. Some parental animals in the top dose group showed signs of behavioural/CNS effects, such as intermittent tremors, repetitive movements of mouth and jaws, and excessive pawing and licking of the cage. The female top dose group also had an increase mean liver weight compared to the control group. The NOAEL for general parental toxicity was therefore concluded to be 300 mg/kg bw/day. However, there were no effects on any reproductive or neonatal parameters assessed, and the NOAEL both for reproduction toxicity and developmental toxicity were concluded to be 1,000 mg/kg bw/day. Therefore, no classification is required.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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