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Diss Factsheets
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EC number: 249-482-6 | CAS number: 29171-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
- Endpoint:
- carcinogenicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- No data
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: The study was not conducted according to a guideline and not performed according to GLP. The publication is relatively short, however the design of the study seems proper and the results are described clearly.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of rat mammary carcinogenesis by monoterpenoids
- Author:
- WA Russin, JD Hoesly, CE Elson, MA Tanner and MN Gould
- Year:
- 1 989
- Bibliographic source:
- Carcinogenesis 10(11): 2161-2164 (1989)
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Mammary tumors were induced by a single gastric intubation of 65 mg/kg 7,12-dimethylbenz[a]anthracene (DMBA) (in 0.5 ml sesame oil) 101 6-week-old female Sprague-Dawley rats, of which 50 were treated with 1% oxygenated (+/-)-linalool in diet for 20 weeks (start: 2 weeks before tumor induction). Number of tumors and latency were recorded in both groups to determine if linalool inhibited mammary carcinogenesis.
- GLP compliance:
- no
Test material
- Reference substance name:
- Linalool
- EC Number:
- 201-134-4
- EC Name:
- Linalool
- Cas Number:
- 78-70-6
- Molecular formula:
- C10H18O
- IUPAC Name:
- 3,7-dimethylocta-1,6-dien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): (+/-)-Linalool (oxygenated)
- Substance type: Monoterpene
- Analytical purity: 96.6%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- other: powdered Way Lab Blox diet
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 20 weeks
- Frequency of treatment:
- Ad libitum
- Post exposure period:
- Not relevant
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1%
Basis:
nominal in diet
- No. of animals per sex per dose:
- Dose group: 50
Control group: 51 - Control animals:
- yes, plain diet
Results and discussion
Results of examinations
- Relevance of carcinogenic effects / potential:
- The chemopreventive potential of linalool was studied, but the substance was found not to possess this ability. Linalool did not increase the tumor frequency when compared to the untreated control group.
Any other information on results incl. tables
Linalool did not significantly extend tumor latency or reduce the total number of tumors observed when compared to controls. Control group animals had an average number of tumours per rat of 2.3, linalool-treated rats 1.9 tumors per rat.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, it can be concluded that 20-week exposure to linalool in the diet did not inhibit DMBA induced mammary carcinogenesis.
- Executive summary:
This study was conducted to determine if the oxygenated monoterpene (+/-)-Linalool inhibits the mammary carcinogenesis in the rat. Therefore, mammary tumors were induced in 101 female rats, of which 50 were treated with 1% Linalool in the diet shortly before and after induction (total 20 weeks). Number of tumors and tumor latency were recorded in each group.
The results indicate that linalool did not significantly extend tumor latency or reduce the total number of tumors observed when compared to controls. Under the conditions of this study, it was concluded that 20-week exposure to linalool in the diet did not inhibit mammary carcinogenesis and as well did not increase tumor frequency.
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