Registration Dossier
Registration Dossier
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EC number: 219-401-9 | CAS number: 2432-11-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: basic information given
Data source
Reference
- Reference Type:
- other: Summary of Results
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Principles of method if other than guideline:
- no guideline available; modified version of the Ames test (OECD 471)
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- m-terphenyl-2'-ol
- EC Number:
- 219-401-9
- EC Name:
- m-terphenyl-2'-ol
- Cas Number:
- 2432-11-3
- Molecular formula:
- C18H14O
- IUPAC Name:
- 3-phenyl-[1,1'-biphenyl]-2-ol
- Details on test material:
- - Name of the test substance used in the study report: 2,6-Diiphenylphenol
-Test substance No.: 10/0493-1
-Batch No.: LV 83/2010
- Purity: 100%
- Date of production: 18 Aug 2010
- Physical state: solid, beige
- Storage conditions: room temperature
Constituent 1
Method
- Target gene:
- histidin operon
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 98
- Species / strain / cell type:
- other: S. typhimurium TA Mix (TA 7001 - TA 7006)
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat liver S9 fraction
- Test concentrations with justification for top dose:
- 0, 4, 20, 100, 500, 2500 and 5000 µg/ml
- Vehicle / solvent:
- DMSO
- Details on test system and experimental conditions:
- Liquid fluctuation test
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Species / strain:
- other: S. typhimurium TA Mix (TA 7001 - TA 7006)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
- Additional information on results:
- .
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Precipitation in plates:
- at 500 µg/m and above (without S9 mix)
- no precipitation occurred (with S9 mix)
A relevant increase in the number of positive wells (his+ revertants) was not observed either without S9 mix or after the addition of a metabolizing system.
Applicant's summary and conclusion
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