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Diss Factsheets
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EC number: 256-170-3 | CAS number: 44914-03-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Additional information
Stability (abiotic transformation) endpoints generally consist of hydrolytic and phototransformation reactions. Hydrolysis is not expected to contribute significantly to the fate of 2-MBA. The related compound n-butyl acrylate (n-BA) has an abiotic hydrolytic half-life of 1100 days at pH 7, 25 °C. 2-MBA is expected to be somewhat less hydrolytically active than n-BA because of the methyl branch adjacent to the ester bond. In addition, 2-MBA and n-BA are readily biodegradable. 2-MBA would be biodegraded in non-sterile aquatic and terrestrial systems well before abiotic hydrolysis would occur. We have proposed adaptation (omission) of the data requirement for hydrolysis for 2-MBA, owing to its ready biodegradability. It is important that phototransformation of 2-MBA in air be considered. 2-MBA is volatile (vapour pressure, 1.7 hPa at 20 °C, Henry's Law constant, 96 Pa*m3/mol at 23.1 °C) and may partition to the atmospheric compartment. A DT50 of 1.04 days for reaction of 2-MBA with hydroxyl radicals was estimated using AOPWIN v.1.92. This software relies on a structure fragment approach to calculating a defined endpoint, the rate constant for reaction of a substance with hydroxyl radical. The training set for this software contains 667 individual chemicals, from which a variety of structural fragments were defined. Partial rate constants for each individual fragment are weighted by a scaling factor and summed to arrive at an overall rate constant for the substance in question. From the log-log plot of derived and experimental hydroxyl radical reaction rate constants for training set chemicals, the correlation coefficient (r2) is 0.963, the standard deviation is 0.218, and the absolute mean error is 0.127. The model is generally valid and applicable for substances which are completely described by the structural fragments developed for the software. 2-MBA contains only structural fragments that are defined within the software, and further the training set itself contains acrylates and methacrylates. 2-MBA is therefore within the applicability domain of the software.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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