Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 603-373-3 | CAS number: 129909-90-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water: sediment simulation testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 835.4300 (Aerobic Aquatic Metabolism)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-amino-N-tert-butyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
- EC Number:
- 603-373-3
- Cas Number:
- 129909-90-6
- Molecular formula:
- C10H19N5O2
- IUPAC Name:
- 4-amino-N-tert-butyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
- Details on test material:
- 3.19 MBq/mg
Constituent 1
- Radiolabelling:
- yes
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- natural water / sediment
- Details on source and properties of surface water:
- Sid White pond (pH 7.4) and Econfina marine (pH 8.1) from Florida
- Details on source and properties of sediment:
- Sid White pond (clay, 0.6% OM, pH 6.2) and Econfina marine (sand, 4.7% OM, pH 7.6) from Florida
- Duration of test (contact time):
- 100 d
Initial test substance concentration
- Initial conc.:
- 0.5 other: micrograms/g
- Based on:
- test mat.
- Details on study design:
- Duplicate samples collected at 0, 7, 14, 30, 62 and 100 days
Results and discussion
- Test performance:
- Aerobic microbial activity was tested and showed that the sediment was viable throughout the study. The systems remained aerobic throughout the study.
% Degradationopen allclose all
- % Degr.:
- 103
- Parameter:
- test mat. analysis
- Sampling time:
- 0 d
- Remarks on result:
- other: Sid White Pond
- % Degr.:
- 82.6
- Parameter:
- test mat. analysis
- Sampling time:
- 100 d
- Remarks on result:
- other: Sid White Pond
- % Degr.:
- 97.2
- Parameter:
- test mat. analysis
- Sampling time:
- 0 d
- Remarks on result:
- other: Econfina Marine
- % Degr.:
- 64.2
- Parameter:
- test mat. analysis
- Sampling time:
- 100 d
- Remarks on result:
- other: Econfina marine
Half-life of parent compound / 50% disappearance time (DT50)open allclose all
- Compartment:
- entire system
- DT50:
- 385 d
- St. dev.:
- 0.763
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT90 1279.2 days Pond
- Compartment:
- entire system
- DT50:
- 182.4 d
- St. dev.:
- 0.959
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: DT90 605.9 days Marine
- Transformation products:
- yes
Identity of transformation productsopen allclose all
- No.:
- #1
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- desamino amicarbazone
- Identifier:
- common name
- Identity:
- desamino amicarbazone
- No.:
- #2
Reference
- Reference substance name:
- Unnamed
- IUPAC name:
- Decarboxamide amicarbazone
- Identifier:
- common name
- Identity:
- Decarboxamide amicarbazone
- Details on transformation products:
- #1 max 4.0% pond, 16.7% marine; #2 max 1.3% pond, 8.0% marine
- Evaporation of parent compound:
- not measured
- Volatile metabolites:
- yes
- Residues:
- yes
- Details on results:
- Bound residues max. 7% at 100 days; CO2 max 0.3% AR at 100 days.
Applicant's summary and conclusion
Validity criteria
- Validity criteria fulfilled:
- yes
- Conclusions:
- Total system DT50s of 385 and 182.4 days with mass balances in the range of 100.7 +/- 3.5% and 99.2 +/- 2.3% for the pond and marine systems respectively.
- Executive summary:
The aerobic aquatic degradation of amicarazone was determined in two water/sediment systems, a pond and a marine system. Amicarbaxone degraded slowly with DT50's of 385.0 and 182.4 days for the pond and marine systems respectively. Mass balances were within the 90 -110% range (95.1 to 108.5% for all samples). The main metabolites were desamino amicarbazone and decarboxamide amicarbazone.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.