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Diss Factsheets
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EC number: 205-527-1 | CAS number: 142-19-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, slightly deviating from guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- Groups of three animals (rabbits), except the high dose group of two animals, were exposed topically to one dermal dose of test substance.
- Principles of method if other than guideline:
- Groups of three animals, except the high dose group of two animals, were exposed topically to one dermal dose of test substance. Animals were observed during a period of 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Allyl heptanoate
- EC Number:
- 205-527-1
- EC Name:
- Allyl heptanoate
- Cas Number:
- 142-19-8
- Molecular formula:
- C10H18O2
- IUPAC Name:
- allyl heptanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 14 days
- Doses:
- 313 mg/kg, 625 mg/kg, 1250 mg/kg and the max dose : 5000 mg/kg
- No. of animals per sex per dose:
- 2 for the max dose and 3 for each dose
- Control animals:
- not specified
Results and discussion
- Preliminary study:
- none
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 810 mg/kg bw
- Mortality:
- 1250 mg/kg lethal (3/3 deaths)
5000 mg/kg lethal (2/2 deaths) - Clinical signs:
- other: at 5000 mg/kg : severe diarrhea in 2/2 at 1250 mg/kg : diarrhea in 1/3 and ataxia in 2/3
- Other findings:
- 0.313 g/kg no effects
0.625 g/kg nonspecific effects (0 deaths)
Any other information on results incl. tables
Route | Dose mg/Kg | Death/ nb. of Animals | Obseravation Day | |||||||||||||
1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | |||
Dermal | 313 | 0/3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
625 | 0/3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
1250 | 3/3 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | |
5000 | 2/2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- other: Toxicity Category III
- Executive summary:
The acute dermal toxicity of allyl heptanoate was assessed in an acute dermal toxicity study performed equivalent or similar to OECD Guideline 402. Groups consisting of 3 rabbits each, except the high dose group of 2 animals, were treated topically with a single dose of 313, 625, 1250 and 5000 mg/kg bw of the target substance. Animals were observed during a period of 14 days. No mortality occurred at 313 and 625 mg /kg bw. All animals died at 1250 and 5000 mg/kg bw. The calculated LD50 value was 810 mg/kg bw.
The available data on acute dermal toxicity meet the criteria for Acute Tox. Cat. 3 (H311) according to Regulation (EC) 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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