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Diss Factsheets
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EC number: 202-090-9 | CAS number: 91-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no guideline study, limited documentation, limited number of endpoints assessed
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
- Principles of method if other than guideline:
- Method: BASF-Test used before OECD Test Guidelines were in place
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 3-diethylaminophenol
- EC Number:
- 202-090-9
- EC Name:
- 3-diethylaminophenol
- Cas Number:
- 91-68-9
- Molecular formula:
- C10H15NO
- IUPAC Name:
- 3-(diethylamino)phenol
- Details on test material:
- - Name of test material (as cited in study report): Diäthyl-m-aminophenol
- Physical state: solid
- Analytical purity: 99 %
- Other: soluble in acetic acid, alcohol, lutrol, ethylenechloride, unsoluble in soda solution and vegetable oil
Constituent 1
Test animals
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2 - 4 kg
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: Traganth
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 1 %, 2 % or 10 % - Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- - 2,4, 12 applications
- 2 cats received 2 applications with 100 or 1000 mg/kg bw ; 1 cat received 4 applications with 50 mg/kg bw ; 1 cat received 12 applications with 50 mg/kg bw - Frequency of treatment:
- - daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50; 100 or 1000 mg/kg bw
Basis:
actual ingested
- No. of animals per sex per dose:
- 1 or 2 cats
- Control animals:
- no
- Positive control:
- no
Examinations
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Yes
BODY WEIGHT: Yes
HAEMATOLOGY: Yes, including methemoglobin
URINALYSIS: Yes - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: No
Results and discussion
Results of examinations
- Details on results:
- Animals which received the higher doses (100 or 1000 mg/kg bw) died after the second application. Symptoms like excessive salivation, vomiting after application as well as ataxia and somnolence were observed. The methemoglobin tests were positive. In both animals the lungs and the liver were dark coloured, the heart was reddishliy dicoloured and/or showed sporadic bleedings. Also the spleen was dark colored and enlarged.
One of the cats which received 50 mg/kg bw died 2 days after the fourth application. Vomiting and salivation were observed. The methaemoglobin tests were positive and the number of haemoglobin decreased constantly. Liquids were detected in the lungs and the intraperitoneally adipose tissue was yellow-coloured.
One animal survived 12 applications of 50 mg/kg bw, only after the first application salivation and vomiting was noticed. No more clinical signs or symptoms were observed after the other applications. No loss of body weight was detected. During the exposure time the number of haemoglobin and of the erythrocytes decreased (haemolytic anaemia).
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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