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EC number: 607-234-8 | CAS number: 234446-82-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study was conducted in accordance with the following Good Laboratory Practice Standards with the exception that analysis of the testmaterial mixture for concentration, homogeneity/solubility, and stability was not conducted.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Magnesium, EDTA cobalt copper iron manganese zinc complexes
- EC Number:
- 607-234-8
- Cas Number:
- 234446-82-3
- Molecular formula:
- Unspecified (UVCB substance)
- IUPAC Name:
- Magnesium, EDTA cobalt copper iron manganese zinc complexes
- Reference substance name:
- TKA 45028
- IUPAC Name:
- TKA 45028
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): TKA 45028
- Physical state: light-green powder
- Composition of test material, percentage of components:
CAS 234446-82-3 is the main component of the product TI name, which is a preparation of approx. 2.5 % disodiumoctaborate , 0.25 % sodiummolybdate and CAS 2344446-82-2. The product also contains approximately 10 % water as residual humidity. The content of CAS 2344446-82-2 in the product is therefore approximately 87 %.
- Purity test date: The Sponsor assumes responsibility for purity and stability determinations
- Lot/batch No.: ELW1099
- Stability under test conditions: The Sponsor assumes responsibility for purity and stability determinations (including under test conditions).
- Storage condition of test material: The test material was stored at room temperature.
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: rats were procured from Charles River Laboratories, Portage, Michigan, on December 13, 1999.
- Age at study initiation: approximately 7 to I I weeks of age
- Weight at study initiation: weighing from 203 to 229 g
- Fasting period before study: for 17 to 20 hours before test material administration
- Housing: After receipt, the animals were acclimated for a period of at least 5 days. During acclimation and throughout the study, the animals were separated by sex and group housed in suspended, stainless steel cages.
- Diet (e.g. ad libitum): continuous access to rodent diet (#8604, Harlan Teklad)
- Water (e.g. ad libitum):continuous access to water
- Acclimation period: After receipt, the animals were acclimated for a period of at least 5 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): I 8 to 26°C
- Humidity (%): 30 to 70%,
- Photoperiod (hrs dark / hrs light): 12-hour light/12-hour dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: distilled water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: The test material was mixed with distilled water to a concentration of 0.4 mg/ml
- Amount of vehicle (if gavage): 5 ml/kg of body weight
- Justification for choice of vehicle: common vehicle
MAXIMUM DOSE VOLUME APPLIED: - Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5
- Details on study design:
- - Duration of observation period following administration: Clinical observations were conducted at 1, 2.5, and 4 hours after test material administration and daily thereafter for 14 days.
- Frequency of observations and weighing:
Body weights were determined before test material administration (Day 0), at Day 7, and at termination of the in-life phase (Day 14).
- Necropsy of survivors performed: yes - Statistics:
- No statistical evaluations were required by the protocol.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: content of TI in product: 87%
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 740 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- No mortality was observed during the study
- Clinical signs:
- other: All an imals appeared normal throughout the study
- Gross pathology:
- There were no visible lesions observed at the macroscopic necropsy examinations conducted at termination.
Applicant's summary and conclusion
- Conclusions:
- No mortality was observed during the study and therefore the estimated oral LD50 values for male and female rats were determined to be greater than 2,000 mg/kg bw.
- Executive summary:
The acute oral toxicity of the test substance was evaluated in male and female rats when administered as a single gavage dose at a Ievel of 2000 mg/kg of body weight. No mortality was observed during the study. The estimated oral LDso values for male and female rats were determined to be greater than 2000 mg/kg. All animals appeared normal and exhibited body weight gain throughout the study. The macroscopic necropsy examinations conducted at termination did not reveal any visible lesions. Based on the results of this study, the acute oral toxicity caused by test substance was insufficient for a risk phrase to be necessary under terms of the General Classification and Labeling Requirements for Dangerous Substances and Preparations, as stated in Annex IV to Commission Directive 93121/EC. The test material is not considered to be a toxic material.
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