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Diss Factsheets
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EC number: 219-144-2 | CAS number: 2372-45-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin corrosion: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17. Jun.- 17. Aug. 2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
- Version / remarks:
- July 19, 2006
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Sodium butanolate
- EC Number:
- 219-144-2
- EC Name:
- Sodium butanolate
- Cas Number:
- 2372-45-4
- Molecular formula:
- C4H10O.Na
- IUPAC Name:
- sodium butan-1-olate
- Details on test material:
- - Name of test material (as cited in study report): Na-n-Butylat Lsg. 20 % (PRD 30285885)
- Physical state: homogenous liquid
- Analytical purity: not given (see test report No.: 11S02637)
- Lot/batch No.: 000STD77L0
- Stability under test conditions: stability under test conditions was guaranteed by the sponsor
Constituent 1
Test animals
- Species:
- other: in vitro
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- MATERIAL AND TECHNICAL EQUIPMENT:
- Corrositex Kit containing reagents required for qualification and categorization screen, biobarrier matrix powder and diluent, membrane discs and vials containing the Chemical Detection System (InVitro International, Irvine, California)
Test system
- Type of coverage:
- open
- Preparation of test site:
- other: not applicable
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Negative Control: 10% citric acid, Positive Control: Sodium Hydroxide, solid
- Amount / concentration applied:
- Qualification Screen:
150 µL
Categorization Screen:
150 µL to tube A and B each
Corrositex Assay:
500 µL - Duration of treatment / exposure:
- Following application of test substance onto the mebranes time until break through of the susbstance is monitored (indicated by change in the Chemical Detection System).
- Observation period:
- up to 240 minutes, for substances determined into category 1 by Categorization screen
upt to 60 minutes, for substances determined into category 2 by Categorization screen - Number of animals:
- not applicable
- Details on study design:
- TEST SUBSTANCE:
- 4 vials were used for the experiment
- first vials was observed for 3 minutes, if no color change was observed the remaining 3 were treated with test substance and time until break through of the substance was monitored and recorded
POSITIVE CONTROL
- one pellet of Sodium Hydroxide was applied on top of membrane and vial was monitored until break through occured
NEGATIVE CONTROL
- 500µL were applied on top of membrane, vial was observed for 60 minutes, if no break through occured, evaluated as being non-corrosive
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- other: other: break through time
- Remarks on result:
- other:
- Remarks:
- Basis: mean. Time point: 15 min 52 sec. (migrated information)
In vivo
- Irritant / corrosive response data:
- The mean break through time determined for Na-n-Butylat Lsg. 20% was 15 minutes and 52 seconds.
- Other effects:
- not applicable
Any other information on results incl. tables
Table2: Findings
Break Through Time [min:s] |
|||||
vial 1 | vial2 | vial 3 | vial 4 | Mean | |
11/0395 -1 | 16:17 | 16:00 | 15:40 | 15:30 | 15:52 |
Controls: | |||||
PC: Sodium Hydroxide, solid | 11:50 | - | - | - | - |
NC: 10% citric acid | NB | - | - | - | - |
Table3: Historical Control Data
mean [min:s] | SD [min:s] | |
Positive Control (NaOH, solid) | 12:38 | 02:45 |
Negative Control (10% citric acid) | NB | - |
NB = no break through within maximum observation period (60 min.)
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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