Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-642-4 | CAS number: 123-68-2
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The substance was not inhibiting to microbial activity at a nominal test concentration of 100 mg/L in the ready biodegradability test.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
The valid study on the ready biodegradability included a toxicity control with the positive reference substance aniline (at 100 mg/L) and the test substance allyl hexanoate (at 100 mg/L). The microbial activity in this toxicity control was not significantly inhibited. According to ECHA guideline R.7b, the non-inhibiting test concentration in the toxicity can be regarded as NOEC for microbial toxicity in the hazard assessment. In contrast, a study on the acute toxicity of allyl hexanoate on the ciliate Tetrahymena pyriformis produced an EC50 value (based on growth inhibition) of 1.63 mg/L. ECHA guidance R.7b says that "preference is given to tests with a mixed inoculum that assess the functioning of the entire microbial community in an STP, rather than tests based on single species or even microbial sub-systems" (page 149). Therefore, the study on Tetrahymena is not considered in the derivation of a threshold value for toxicity to micro-organism and the PNEC STP will be based on the non-inhibitory concentration applied in the toxicity control of the study on ready biodegradability conducted with non-adapted activated sludge.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
