Registration Dossier
Registration Dossier
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EC number: 700-111-0 | CAS number: 148528-05-6
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Data source
Materials and methods
Test material
- Reference substance name:
- (2R)-2-methyloctane-1,8-diamine; (2S)-2-methyloctane-1,8-diamine
- EC Number:
- 700-111-0
- Cas Number:
- 148528-05-6
- Molecular formula:
- C9H22N2
- IUPAC Name:
- (2R)-2-methyloctane-1,8-diamine; (2S)-2-methyloctane-1,8-diamine
Constituent 1
Results and discussion
Any other information on results incl. tables
Based on the physical characteristics of this test substance it is likely that it will be absorbed dermally, and will produce high pH values when in contact with moisture either from the skin or the ocular environment. The oral gavage studies indicate that aqueous preparations of the test substance resulted in trauma (gastrointestinal haemorrhage, erosion and ulceration) and adaptive changes (mucosal hyperplasia in the fore-stomach associated with oedema and cellular infiltration) which are considered to be due to the administration of a strongly alkaline preparation.
Applicant's summary and conclusion
- Conclusions:
- It is considered that performing irritancy studies via the dermal or ocular routes are unlikely to yield any additional data to those already available. It is considered the risk phrase R35 'Causes severe burns' should be assigned to MODA.
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