Diammonium [[N,N'-ethylenebis[N-(carboxymethyl)glycinato]](4-)-N,N',O,O',ON,ON']hydroxyferrate(2-)

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Well conducted non-GLP study. The study was performed according to methods similar to OECD407/408. Only male rats were used. 10 male animals were sacrificided at the beginning of the experiment in order to establish baseline levels of the analytical parameters to be measured. No other data were collected for these animals. No further control group was included.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Disposition, accumulation and toxicity of iron fed as iron (11) sulfate or as sodium iron EDTA in rats

Author:

Appel, M. J. , Kuper, C.F., Woutersen, R.A.

Year:

2001

Bibliographic source:

Food and Chemical Toxicology 39 261-269

Materials and methods

Test material

Test material information

Constituent 1

Reference substance name:

Sodium feredetate

EC Number:

239-802-2

EC Name:

Sodium feredetate

Cas Number:

15708-41-5

Molecular formula:

C10H12N2O8FeNa

IUPAC Name:

Sodium; 2-[2-(bis(carboxylatomethyl)amino)ethyl-(carboxylatomethyl)amino]acetate; iron(+3) cation