Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex

Density

Link to relevant study record(s)

Reference

Endpoint:

density, other

Remarks:

density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

16-03-2017 – 16-03-2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Justification for type of information:

Experimental test result performed using standard OECD test guidelines

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Principles of method if other than guideline:

The density of Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex was determined by OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014

GLP compliance:

not specified

Type of method:

other: By method recommended in the International Pharmacopoeia, fourth Edition, 2014

Specific details on test material used for the study:

- Name of test material: Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex
- IUPAC name: aluminum tris(4-{[3-carboxy-5-oxo-1-(4-sulfophenyl)-4,5-dihydro-1H-pyrazol-4-yl]diazenyl}benzenesulfonate)
- Molecular formula: C48H33AlN12O27S6
- Molecular weight: 1429.19 g/mole
- Smiles : C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)O)C(=O)O)S(=O)(=O)[O-].C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)O)C(=O)O)S(=O)(=O)[O-].C1=CC(=CC=C1N=NC2C(=NN(C2=O)C3=CC=C(C=C3)S(=O)(=O)O)C(=O)O)S(=O)(=O)[O-].[Al+3]
- Inchl: 1S/3C16H12N4O9S2.Al/c3*21-15-13(18-17-9-1-5-11(6-2-9)30(24,25)26)14(16(22)23)19-20(15)10-3-7-12(8-4-10)31(27,28)29;/h3*1-8,13H,(H,22,23)(H,24,25,26)(H,27,28,29);/q;;;+3/p-3
- Substance type: Organic
- Physical state: Solid Red powder

Key result

Type:

pour density

Density:

0.283 g/cm³

Temp.:

26.8 °C

Remarks on result:

other: at 977.9 hPa

Key result

Type:

tap density

Density:

0.341 g/cm³

Temp.:

26.8 °C

Remarks on result:

other: at 977.9 hPa

TEST ITEM DESCRIPTION AND RESULTS

FOR SOLIDS:

By Pour Density and Tapped Density Method:

Method Details		Observations		Remarks if, any
Guideline	OECD 109	1st Reading	2nd Reading
Method	Test methods: Pour density and tapped density of powders recommended in The International Pharmacopoeia, Fourth Edition, 2014
Principle of method	Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder. Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.
Test temperature (°C)	-	26.9°C	26.7°C
Atmospheric pressure (in hPa)	-	978.1	977.7
Weight of test item(m)		20.108	20.105
Volume of measuring cylinder; readability in g		250 ml; 2 ml	250 ml; 2 ml
Volume of test item without tapping (V)		72	70
Volume of test item after tapping ( V1)	After 10 tapping	64	62
	After 50 tapping	60	58
	After 100 tapping	60	58
	After 250 tapping	-	-
	After 500 tapping	-	-
	After 750 tapping	-	-

*ρat=density of air at 27°C and 760 mm Hg pressure=0.001168 g/cm³

**Density of water referred from the Table 1 of the was method.

 

 

FOR SOLIDS:

By Pour Density and Tapped Density Method:

 

Parameters	Details	Calculated values		Average Density
		1st Calculation	2nd Calculation
Pour Density of test Item (g/cm³)	= m / V	0.2792	0.2872	0.2832
Tap density of test Item (g/cm³)	= m / V1	0.3351	0.3466	0.3408

 

Conclusions:

The mean pour density and tapped density of Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex (CAS No. 12225-21-7) is determined to be 0.2832 g/cm³ and 0.3408 g/cm³ at 26.8°C and 977.9 hPa.

Executive summary:

The density of test item Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex (CAS No. 12225-21-7) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density appratus.

The mean pour density and tapped density of test item is determined to be 0.2832 g/cm³ and 0.3408 g/cm³ at 26.8°C and 977.9 hPa.

Description of key information

The mean pour density and tapped density of Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]- 1H-pyrazole-3-carboxylic acid complex (CAS No. 12225-21-7) is determined to be 0.2832 g/cm³ and 0.3408 g/cm³ at 26.8°C and 977.9 hPa.

Key value for chemical safety assessment

Relative density at 20C:

0.341

Additional information

The density of test item Aluminium, 4,5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl)azo]-1H-pyrazole-3-carboxylic acid complex (CAS No. 12225-21-7) was determined following OECD Guideline 109 and according to the Test methods: Pour density and tapped density of powders” recommended in The International Pharmacopoeia, Fourth Edition, 2014 using bulk density appratus.

The mean pour density and tapped density of test item is determined to be 0.2832 g/cm³ and 0.3408 g/cm³ at 26.8°C and 977.9 hPa.

Other supporting data from another report, determined the bulk density of aluminium,4, 5-dihydro-5-oxo-1-(4-sulfophenyl)-4-[(4-sulfophenyl) azo]-1H-pyrazole-3-carboxylic acid complex by the mass by volume method as 0.353 g/cm3 at room temperature of 28 deg C.