Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
specific investigations: other studies
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed

Materials and methods

Principles of method if other than guideline:
Test procedure:
OECD guideline 486, adopted 21st July 1997

Results and discussion

Details on results:
Clinical signs (including activity and piloerection) were
observed at both dose levels of the test substance after the
second administratioin. One animal dosed at 2000 mg/kg was
found dead shortly before the start of liver perfusion.

The viability of the hepatocytes was not substantially
affected by the in vivo treatment with the test item at any
of the dose groups.

None of the tested dose levels revealed UDS induction in the
hepatocytes of the treated animals as compared to the
corresponding vehicle control.

Applicant's summary and conclusion