Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2005

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Screening test
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diethyl fluoromalonate
EC Number:
211-684-7
EC Name:
Diethyl fluoromalonate
Cas Number:
685-88-1
Molecular formula:
C7H11FO4
IUPAC Name:
1,3-diethyl 2-fluoropropanedioate

Test animals

Species:
rat
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: methylcellulose
Doses:
300, 100 and 50 mg/kg
No. of animals per sex per dose:
3
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
< 50 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

 

Test

substance

 

Dose levels

(mg/kg)

 

Mortality incidence

 

 

Number of death

diethyl fluoromalonate

300

3/3

diethyl fluoromalonate

100

3/3

diethyl fluoromalonate

50

2/3

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category II
Remarks:
Migrated information Criteria used for interpretation of results: EU