Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 213-554-5 | CAS number: 976-71-6
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: short abstract
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicologic evaluation of aldadiene
- Author:
- McLain DE et al.
- Year:
- 1 990
- Bibliographic source:
- J. American College Toxicology, Part B. Vol. 1, pp. 36-37, 1990
Materials and methods
- Principles of method if other than guideline:
- no data
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Canrenone
- EC Number:
- 213-554-5
- EC Name:
- Canrenone
- Cas Number:
- 976-71-6
- Molecular formula:
- C22H28O3
- IUPAC Name:
- 10,13-dimethyl-1,8,9,10,11,12,13,14,15,16-decahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
- Reference substance name:
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone
- IUPAC Name:
- Pregna-4,6-diene-21-carboxylic acid, 17-hydroxy-3-oxo-, .gamma.-lactone
- Test material form:
- solid - liquid: suspension
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- - Application volume: 10 ml/kg
- Doses:
- 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- no data
Results and discussion
- Preliminary study:
- no data
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
No remarkable clinical signs.
Applicant's summary and conclusion
- Executive summary:
A single oral administration of the test substance by gavage to male and female rats at the limit-dose 5000 mg/kg was tolerated without remarkable clinical signs (LD50 > 5000 mg/kg body weight).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
