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Diss Factsheets
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EC number: 800-309-8 | CAS number: 231297-75-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to guidelines, but not to GLP and not fully reported.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSA 16CFR 1500.3
- Deviations:
- no
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Details on test material:
- - Name of test material (as cited in study report): alkaryl magnesium salt derivative (CAS 71786-47-5)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- single dose of undiluted test material administered by oral gavage (intragastrically)
MAXIMUM DOSE VOLUME APPLIED: 16 ml/kg bw
Dose volumes: 1, 2, 4, 8 and 16 mL/kg - Doses:
- 1000, 2000, 4000, 8000 and 16000 mg/kg bw
- No. of animals per sex per dose:
- 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Weights were recorded on day of dosing and at termination
- Necropsy of survivors performed: yes - Statistics:
- Use of statistics not indicated
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 16 000 mg/kg bw
- Remarks on result:
- other: 95% CL not determined
- Mortality:
- Mortality did not occur in treated animals. No deaths were observed during the 14-day observation period.
- Clinical signs:
- other: Animals dosed with 8000 and 16000 mg/kg bw exhibited ruffled fur for 18-24 hours post dosing. They appeared normal within 48 hours.
- Gross pathology:
- No treatment related effects were observed on necropsy.
Any other information on results incl. tables
Table 2: Number of animals dead [and with evident toxicity] [and time range within which mortality occurred]
Dose |
Mortality (# dead/total) |
Time range of deaths (hours) |
Number with evident toxicity (#/total) |
||||
Male |
Female |
Combined |
Male |
Female |
Combined |
||
1000 |
0/5 |
- |
- |
- |
0/5 |
- |
- |
2000 |
0/5 |
- |
- |
- |
0/5 |
- |
- |
4000 | 0/5 | - | - | - | 0/5 | - | - |
8000 | 0/5 | - | - | - | 5/5 | - | - |
16000 | 0/5 | - | - | - | 5/5 | - | - |
No deaths were observed during the 14-day observation period. The animals at 8 and 16 g/kg exhibited ruffled fur for 18-24 hours post dosing. Within 48 hours all animals appeared normal. No body weight effects were observed. Gross necropsy findings were unremarkable.
The test article, when administered as received to male Sherman-Wistar rats, had an acute oral LD50 of greater than 16.0 g/kg
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Mortality did not occur at doses of 16000 mg/kg bw, therefore an LD50 was not determined.
- Executive summary:
In an acute oral toxicity study, groups of 5 male Sherman rats were given a single oral dose of alkaryl magnesium salt derivatives at doses of 1000, 2000, 4000, 8000 and 16000 mg/kg bw and observed for 14 days. No mortality occurred, therefore an LD50 has not been determined. Animals dosed with 8000 and 16000 mg/kg bw exhibited ruffled fur for 18-24 hours post dosing but they appeared normal within 48 hours. No significant change in bodyweights occurred in treated animals. No treatment related effects were observed on necropsy. This acute oral toxicity study is acceptable. It satisfies the guideline requirement for an acute oral study in the rat. The test article, when administered as received to male Sherman-Wistar rats, had an acute oral LD50 of greater than 16.0 g/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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