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EC number: 931-505-2 | CAS number: 1335202-77-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1973-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because while this study predates GLP guidance, the limited information provided indicates that this study was conducted in a manner similar to OECD 403 guideline.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Study period:
- 1973-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because while this study predates GLP guidance, the limited information provided indicates that this study was conducted in a manner similar to OECD 403 guideline.
- Justification for type of information:
- A discussion and report on the read across strategy is given as an attachment in Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data reported.
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- A 34 litre chamber was saturated by passing all air flowing into the chamber through a container of the liquid material at a rate of 2.75 litres per minute.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- > 1 - <= 4 h
- Concentrations:
- Limit test concentration was 87.5 mg/L of 1-octene for 1 hour.
Four hour LC50 test concentrations were 28.0, 31.1, 36.0, 40.5, 48.4, and 53.6 mg/L of 1-octene. - No. of animals per sex per dose:
- Limit test: 10 animals/male/87.5 mg/L
Four hour LC50 test: 10 animals/male/28.0 mg/L; 10 animals/male/31.1 mg/L; 10 animals/male/36.0 mg/L; 10 animals/male/40.5 mg/L; 10 animals/male/48.4 mg/L; and 10 animals/male/53.6 mg/L - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days for surviving animals
- Frequency of observations and weighing: No data reported.
- Necropsy of survivors performed: Yes - Statistics:
- No data reported.
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 8 050 ppm
- 95% CL:
- > 6 600 - <= 9 800
- Exp. duration:
- 4 h
- Remarks on result:
- other: Equivalent to 40,240 mg/m3 (40.2 mg/L)
- Mortality:
- Limit test: 9/10 animals expired at the end of the one hour exposure.
Four hour LC50 test:0/10 animals expired at 28.0 mg/L; 2/10 animals expired at 31.1 mg/L; 5/10 animals expired at 36.0 mg/L; 6/10 animals expired at 40.5 mg/L; 9/10 animals expired at 48.4 mg/L; and 10/10 animals expired at 53.6 mg/L - Clinical signs:
- other: Observations during the four hour LC50 test revealed diaphragmatic breathing, erythema of exposed skin sites, and body tremors.
- Body weight:
- Not data reported.
- Gross pathology:
- Gross necropsy performed on the dead animals in the limit test indicated hemorrhagic lungs, very pale kidneys, and congestive hepatopathy.
Autopsy at the end of the 14-day observation period for the four hour LC50 test indicated that there were no significant pathological changes - Other findings:
- - Other observations: Surviving animals showed immediate recovery once test chemical exposure was ceased and the animals were exposed to fresh air
- Interpretation of results:
- other:
- Remarks:
- Not classified because LC50 is greater than the requirements for a Category 4 vapour toxicant (20 mg/L) Criteria used for interpretation of results: EU
- Conclusions:
- Autopsy at the end of the 14-day observation period indicated that there were no significant pathological changes. Based on these results, that study authors concluded that the LC50 for 1-octene in male Sprague-Dawley rats for a four hour exposure period is 8050 parts per million, with a 95% confidence interval of 6600-9800 parts per million.
- Executive summary:
In an acute inhalation toxicity study, a limit test was first performed on a group of 10 young male adult Sprague-Dawley rats. The animals were exposed to 87.5 mg/L of 1-octene for one hour. After one hour of exposure nine out of ten animals were found dead. Following the limit test a four hour LC50 inhalation toxicity study was performed on 6 groups, 10 per group, of male Sprague-Dawley rats which were exposed to 1octene, whole body, by inhalation route for four hours (vapour atmosphere) at exposure concentrations of 28.0, 31.1, 36.0, 40.5, 48.4, and 53.6 mg/L. Based on the results study authors concluded that the LC50 for 1-octene in male Sprague-Dawley rats for a four hour exposure period is 8050 parts per million, with a 95% confidence interval of 6600-9800 parts per million.
This study was given a Klimisch score of 2 and was classified as reliable with restrictions because while this study predates GLP guidance, the limited information provided indicates that this study was conducted in a manner similar to OECD 403 guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- not specified
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Reference substance 001
- Cas Number:
- 111-66-0
- Molecular formula:
- C8H16
- Details on test material:
- - Name of test material (as cited in study report): 1-Octene alpha olefin C8
- Substance type: C8 alpha olefin
- Physical state: Liquid
- Other: Density 0.716 g/mL
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No data reported.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- A 34 litre chamber was saturated by passing all air flowing into the chamber through a container of the liquid material at a rate of 2.75 litres per minute.
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- > 1 - <= 4 h
- Concentrations:
- Limit test concentration was 87.5 mg/L of 1-octene for 1 hour.
Four hour LC50 test concentrations were 28.0, 31.1, 36.0, 40.5, 48.4, and 53.6 mg/L of 1-octene. - No. of animals per sex per dose:
- Limit test: 10 animals/male/87.5 mg/L
Four hour LC50 test: 10 animals/male/28.0 mg/L; 10 animals/male/31.1 mg/L; 10 animals/male/36.0 mg/L; 10 animals/male/40.5 mg/L; 10 animals/male/48.4 mg/L; and 10 animals/male/53.6 mg/L - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days for surviving animals
- Frequency of observations and weighing: No data reported.
- Necropsy of survivors performed: Yes - Statistics:
- No data reported.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 8 050 ppm
- 95% CL:
- > 6 600 - <= 9 800
- Exp. duration:
- 4 h
- Remarks on result:
- other: Equivalent to 40,240 mg/m3 (40.2 mg/L)
- Mortality:
- Limit test: 9/10 animals expired at the end of the one hour exposure.
Four hour LC50 test:0/10 animals expired at 28.0 mg/L; 2/10 animals expired at 31.1 mg/L; 5/10 animals expired at 36.0 mg/L; 6/10 animals expired at 40.5 mg/L; 9/10 animals expired at 48.4 mg/L; and 10/10 animals expired at 53.6 mg/L - Clinical signs:
- other: Observations during the four hour LC50 test revealed diaphragmatic breathing, erythema of exposed skin sites, and body tremors.
- Body weight:
- Not data reported.
- Gross pathology:
- Gross necropsy performed on the dead animals in the limit test indicated hemorrhagic lungs, very pale kidneys, and congestive hepatopathy.
Autopsy at the end of the 14-day observation period for the four hour LC50 test indicated that there were no significant pathological changes - Other findings:
- - Other observations: Surviving animals showed immediate recovery once test chemical exposure was ceased and the animals were exposed to fresh air
Applicant's summary and conclusion
- Interpretation of results:
- other:
- Remarks:
- Not classified because LC50 is greater than the requirements for a Category 4 vapour toxicant (20 mg/L) Criteria used for interpretation of results: EU
- Conclusions:
- Autopsy at the end of the 14-day observation period indicated that there were no significant pathological changes. Based on these results, that study authors concluded that the LC50 for 1-octene in male Sprague-Dawley rats for a four hour exposure period is 8050 parts per million, with a 95% confidence interval of 6600-9800 parts per million.
- Executive summary:
In an acute inhalation toxicity study, a limit test was first performed on a group of 10 young male adult Sprague-Dawley rats. The animals were exposed to 87.5 mg/L of 1-octene for one hour. After one hour of exposure nine out of ten animals were found dead. Following the limit test a four hour LC50 inhalation toxicity study was performed on 6 groups, 10 per group, of male Sprague-Dawley rats which were exposed to 1octene, whole body, by inhalation route for four hours (vapour atmosphere) at exposure concentrations of 28.0, 31.1, 36.0, 40.5, 48.4, and 53.6 mg/L. Based on the results study authors concluded that the LC50 for 1-octene in male Sprague-Dawley rats for a four hour exposure period is 8050 parts per million, with a 95% confidence interval of 6600-9800 parts per million.
This study was given a Klimisch score of 2 and was classified as reliable with restrictions because while this study predates GLP guidance, the limited information provided indicates that this study was conducted in a manner similar to OECD 403 guideline.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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