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EC number: 231-166-4 | CAS number: 7440-58-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study, performed without any deviation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- Hafnium
- EC Number:
- 231-166-4
- EC Name:
- Hafnium
- Cas Number:
- 7440-58-6
- Molecular formula:
- Hf
- IUPAC Name:
- hafnium
- Test material form:
- other: shot
- Details on test material:
- Appearance: Silver grey/shot
Purity: Hf + Zr> 98% (Zr content: <1.5%)
Expiry date: 21 November 2014
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Research Models and Services, Germany GmbH, Sandhofer Weg 7, D-97633 Sulzfeld
- Age at study initiation: 8-9 weeks old
- Weight at study initiation: 187 – 204 g
- Fasting period before study: The food but not water was withheld during an overnight period.
- Housing: 3 animals/ cage (Cage type: Type II polypropylene/polycarbonate)
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3 °C
- Humidity (%): 30 - 70 %
- Air changes (per hr): 15-20
- Photoperiod: Lighting period: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- distilled water
- Details on oral exposure:
- VEHICLE
- Amount of vehicle (if gavage): 10 mL/kg bw
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: Initially, three female animals were treated with 2000 mg/kg bw of Hafnium because no litterature or other study could indicate a potential hazard of hafnium by ingestion. No mortality was observed, therefore further 3 animals were treated at the dose level of 2000 mg/kg bw. - Doses:
- Initially, three female animals were treated with 2000 mg/kg bw of Hafnium. No mortality was observed, therefore further 3 animals were treated at the dose level of 2000 mg/kg bw.
- No. of animals per sex per dose:
- 3 females per group
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Clinical observations were performed at 30 minutes, 1, 2, 3, 4 and 6 hours after dosing and daily for 14 days thereafter. Body weight was measured on Days -1, 0 and 7 and before necropsy.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic findings
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 cut off
- Mortality:
- Hafnium did not cause mortality at a dose level of 2000 mg/kg bw.
- Clinical signs:
- other: Treatment with Hafnium did not cause any test item related adverse effect during the 14 days observation period.
- Gross pathology:
- There was no evidence of the test item-related macroscopic observations at a dose level of 2000 mg/kg bw. Bilateral dilatation of the uterine horns, body and cervix in 1/6 female was considered to be a common background observation, and is usually associated with physiological changes during oestral cycle in females and not related to the administration of test item.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- Under the conditions of this study, the acute oral LD 50 value of the test item Hafnium was found to be above 2000 mg/kg bw in female CRL:(WI) rats. According the GHS criteria, Hafnium should be ranked as "Category 5" or "Unclassified".
- Executive summary:
The single-dose oral toxicity of Hafnium was performed according to the acute toxic class method (OECD 423) in CRL:(WI) rats.
Two groups of three female rats were treated with Hafnium at a dose level of 2000 mg/kg bw by gavage.
Clinical observations were performed at 30 minutes, 1, 2, 3, 4 and 6 hours after dosing and daily for 14 days thereafter. Body weight was measured on Days -1, 0 and 7 and before necropsy. All animals were subjected to a necropsy and a macroscopic examination.
Hafnium did not cause mortality at a dose level of 2000 mg/kg bw, and the treatment did not cause any test item related adverse effect during the 14 days observation period. Body weight gains of Hafnium treated animals during the study showed no indication
of a treatment-related effect. There was no evidence of the test item-related macroscopic observations at a dose level of 2000 mg/kg bw.
In the conditions of this reliable study (Klimlisch 1 reliability, for a GLP study performed without any deviation), the acute oral LD 50 value of the test item Hafnium was found to be above 2000 mg/kg bw in female CRL:(WI) rats.
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