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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 902-591-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil microorganisms
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
In accordance with section 1.2 of Annex XI to Regulation EC 1907/2006 (REACH) short-term testing of toxicity to soil microorganisms is considered scientifically not necessary and was waived.
Key value for chemical safety assessment
Additional information
According to section 1.2 (weight of evidence) of Annex XI to Regulation (EC) No 1907/2006 weight of evidence from several independent sources of information leading to the assumption/conclusion that a substance has or has not a particular dangerous property may be sufficient to address a specific endpoint. It is moreover specified that “where sufficient weight of evidence for the presence or absence of a particular dangerous property is available (…) further testing not involving vertebrate animals may be omitted.”
The registration substance was assessed to be readily biodegradable (see IUCLID section 5.2.1) and there is no indication that it has potential to bioaccumulate or adsorb to the soil matrix (please see IUCLID section 5.4.1). Based on its intrinsic properties the substance is not regarded to be PBT or vPvB (please refer to IUCLID section 2.3). Thus, in case of indirect exposure of soil, the substance is expected to rapidly degrade and not to persist or bioaccumulate. By following worst case assumptions the registration substance is not classified for environmental hazards in accordance with Regulation (EC) No 1272/2008 (CLP), as amended for the fifteenth time in Regulation (EU) No 2020/1182 (please see endpoint summary for IUCLID chapter 6). Furthermore, chemical safety assessments revealed that the registration substance as well as its structural analogues Methanol and Methyl acetate do not bear any risk for the environment (please refer to the chemical safety report attached to IUCLID section 13 and to the disseminated ECHA REACH dossiers for the read across source substances).
Studies on the toxicity of Methanol and Methyl acetate demonstrated that both source substances are not hazardous to aquatic microorganisms (please refer to IUCLID section 6.1.7). Steinhäuser (1989) carried out a "Mikrotoxtest" with Methyl acetate and derived a EC10 and EC50 (16h) of 1730 mg/L and 6100 mg/L, respectively. Bringmann and Kuehn (1978) determined a toxic treshold value (TGK) of 530 mg/L in a 192-hour test with Microcystis aeruginosa. The same authors report a further toxic threshold value resulting from a cell multiplication test for 16 hours, using two Pseudomonas species, at 6600 mg/L (Bringmann and Kuehn 1977). An IC50 value >1000 mg/L for activated sludge is reported by Klecka et al. (1985). This test was performed according to the OECD Guideline 209 (activated sludge, respiration inhibition test) and is considered the most appropriate for assessing the risk for aquatic microorganisms.
In conclusion, soil is not expected to be a compartment of concern and hazard to soil microorganisms is considered negligible. Therefore, further testing is scientifically not justified and was waived in accordance with section 1.2 (weight of evidence) of Annex XI to Regulation (EC) No 1907/2006.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.