Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-660-0 | CAS number: 27794-93-0
Endpoint summary
Administrative data
Description of key information
The key studies for skin and eye irritation found the potassium salt not irritating to the skin or eye of rabbits (Springborn Laboratories, 2000;rel 1).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
The key studies were selected and deemed sufficient for the irritation endpoints as they were recent, conducted according to guideline and of high reliability (1).
Justification for classification or non-classification
The tested ATMP salts do not exhibit extreme pH (=<2 or =>11.5), therefore local effects on the skin and eye due primarily to high or low pH would not be anticipated. Reliable studies on several different formulations consistently demonstrate a low degree of irritation, well below the threshold for classification.
No data are available on lower or higher pH salts with x=1 or x=6. For these it is more appropriate to base classification on that proposed for ATMP acid.
It is concluded that classification for eye irritation or corrosion is not required for ATMP salts with x=2-5.
For ATMP salts where x=1 or x=6, classification for eye irritation in Category 2 (H319) may be appropriate.
Since ATMP acid does not exhibit skin irritation or corrosion leading to classification, these salts would also be expected to exhibit only mild irritant effects on the skin.It is concluded that classification for skin irritation or corrosion is not required for ATMP salts.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
