Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

It was concluded that 1000 mg/kg/day was the no observed adverse effect level (NOAEL) for parental growth, reproductive performance and offspring growth in this screening study.


Short description of key information:
An OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test) GLP study was conducted, a synopsis is given below.

Effects on developmental toxicity

Description of key information
No evidence was found for developmental effects in the OECD Guideline 421 (Reproduction / Developmental Toxicity Screening Test) study.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

1000 mg.kg/day had no adverse effects on the progress or outcome of the pregnancies.

Justification for classification or non-classification

According to Directive 67/548/EEC and Regulation (EC) 1272/2008, no classification is warranted.

Additional information