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EC number: 247-728-7 | CAS number: 26479-35-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Cheng et al. (2005) investigated the stability of 3 mM potassium allophonate in 10, 50, or 100 mM sodium phosphate buffer at pH 8.0, in 100 mM sodium phosphate buffer at pH 7.3, and in 7.3 mM sodium phosphate buffer at acidic pH (achieved by addition of perchloric acid) in 14-hour hydrolysis assays. Allophonate readily underwent decarboxylation to exclusively form urea at neutral and acidic pHs and in moderate to high buffer concentrations. When potassium allophonate was treated with 0.5 N perchloric acid, a half-life of seconds to minutes was determined. In 10 mM phosphate buffer at pH 8.0, a half-life of ca. 50 hours was estimated. When tested with 100 mM buffer, the estimated half life decreased significantly to ca. 17 hours. When tested with 100 mM buffer at pH 8.0, the half life was determined to be 3 hours. Providing supporting information for stability at alkaline pH, a hydrolysis study performed on potassium allophonate in a sodium phosphate buffer (pH 8.0), found that potassium allophonate was stable to hydrolysis (Ricerca Biosciences, 2013). These data show that hydrolysis of potassium allophonate to urea will proceed at environmentally-relevant pH and that the rate of transformation increases as the pH becomes more acidic.
References:
Cheng, G., Shapir, N., Sadowsky, M. J. and Wackett, L. P. 2005. Allophonate hydrolase, not urease, functions in bacterial cyanuric acid metabolism. Applied and Environmental Microbiology, 71(8): 4437 -45.
Ricerca Biosciences, LLC. 2013. Metabolic Stability of Potassium Allophonate and Formation of Urea in Rat Liver Microsomes. Testing laboratory: Ricerca Biosciences, LLC, Drug Safety and Metabolism, 7528 Auburn Road, Concord OH 44077. Report no.: 029722. Report date: 2013-03-01.
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