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EC number: 200-861-4 | CAS number: 75-33-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No studies are available on the registered substance. The potential for irritancy was evaluated on the basis of the data available on propane-1 -thiol and propane-2 -thiol. Therefore, the registered substance is not considered to be irritating to skin, eyes and respiratory tract.
Skin irritation
Study on propane-2 -thiol
As prescribed in U.S. DOT guideline 49 CFR 173.240, one -half ml of undiluted propane-2-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits (Latven, 1977). The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible. Propane-2-thiol is almost slightly irritating to the skin.
Study on propane-1-thiol
As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-1-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits (Latven, 1976). The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, no effects were discernible at any of the treated skin sites. Propane-1-thiol is not irritating to the skin.
Eye irritation
Study on propane-2-thiol
In a preguideline study (Latven, 1977), a 0.1 ml dose of propane-2-thiol was instilled into one eye of six rabbits. Irritation was scored at 10 min and 1, 2, 3, 4, 24, 48 and 72 hours. The only effect was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected. The responses recovered within 24 hours in five of six rabbits while the sixth animal recovered within 48 hours. Propane-2-thiol is a minimal eye irritant.
Study on propane-1-thiol
In a preguideline study (Latven, 1958), an unreported amount of propane-1-thiol was instilled into the conjunctival sac of the eyes of three rabbits. Eyes were exposed for 60 seconds followed by wiping with a cotton swab, and exposed for 10 seconds followed by flushing the eyes with saline. Animals then were observed for 7 days. Irritation was scored by the method of Draize. Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days. Propane-1-thiol is slightly irritating to the eyes.
Respiratory irritation
Propane-2-thiol is not a respiratory tract irritant in mice after an acute inhalation exposure of 1 min up to the concentration of 36.07 mg/l (Pence, 1983b). In 4-hour acute inhalation toxicity studies (Pence, 1983a; Hardy and, 1987a and 1987b), signs of an irritant effect, including partial closing of eyes, reduced respiratory rate, abnormal respiratory movements were observed during exposure to high concentrations.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- other: US DoT guideline no. 49 CFR 173.240
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No detail available
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours
- Number of animals:
- 6
- Irritation parameter:
- erythema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible.
- Other effects:
- Initial skin contact evoked a mild pain reaction
- Interpretation of results:
- GHS criteria not met
- Executive summary:
As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-2 -thiol was applied to the intact skin site under standard gauze patches of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, moderate erythema (score 2) was present at all of the treated sites, this dissipated completely overnight. No other signs of skin irritation were discernible. Propane-2 -thiol is almost slightly irritating to skin.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable without restriction because it was conducted according to or similar to guideline.
- Qualifier:
- according to guideline
- Guideline:
- other: US DoT guideline no. 49 CFR 173.240
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or test system and environmental conditions:
- No data
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- up to 72 hours
- Number of animals:
- 6
- Irritation parameter:
- erythema score
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- other: all animals
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- No effects were discernible at any of the treated skin sites.
- Interpretation of results:
- GHS criteria not met
- Executive summary:
As prescribed in 49 CFR 173.240, one -half ml of undiluted propane-1-thiol was applied to the intact skin site under standard gauze patches of six albino rabbits. The entire fur-clipped trunk of each animal was then covered with an impervious sleeve for a skin-contact period of 4 hours and then observed during 3 days. When exposures were terminated, no effects were discernible at any of the treated skin sites.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Draize method
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: Albino
- Details on test animals or tissues and environmental conditions:
- No detail available
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- Not rinsed
- Observation period (in vivo):
- 10 min and 1, 2, 3, 4, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
SCORING SYSTEM: Draize scale
TOOL USED TO ASSESS SCORE: No data - Irritation parameter:
- conjunctivae score
- Basis:
- animal: 1 to 5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 3
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- chemosis score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: 1 to 6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritant / corrosive response data:
- The only effec was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a preguideline study, a 0.1 ml dose of iso-propyl mercaptan was instilled into one eye of six rabbits. Irritation was scored at 10 min and 1, 2, 3, 4, 24, 48 and 72 hours. The only effect was conjunctival inflammation with or without chemosis. Neither the cornea nor the iris was effected. The responses recovered within 24 hours in five of six rabbits while the sixth animal recovered within 48 hours. Iso-propyl mercaptan is a slight eye irritant.
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Reporting of the study methods and results was limited.
- Principles of method if other than guideline:
- Draize test
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No data reported
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- No data
- Duration of treatment / exposure:
- 60 seconds, and 10 seconds followed by saline flush
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 3 animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): cotton swab or flushed with saline
SCORING SYSTEM:
Draize scoring method
TOOL USED TO ASSESS SCORE: hand-slit lamp / biomicroscope / fluorescein
No data reported - Irritation parameter:
- other: Maximal corneal irritation score
- Basis:
- animal: 1 to 3
- Time point:
- 24 h
- Score:
- ca. 13
- Max. score:
- 30
- Reversibility:
- fully reversible within: 2 days
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not available
- Irritation parameter:
- conjunctivae score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not available
- Irritation parameter:
- chemosis score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not available
- Irritation parameter:
- iris score
- Basis:
- animal: all
- Time point:
- 24/48/72 h
- Remarks on result:
- other: not available
- Other effects:
- No data reported
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days.
- Executive summary:
In a primary eye irritation study, an unreported amount of propane-1 -thiol was instilled into the conjunctival sac of the eyes of three rabbits. Eyes were exposed for 60 seconds followed by wiping with a cotton swab, and exposed for 10 seconds followed by flushing the eyes with saline. Animals then were observed for 7 days. Irritation was scored by the method of Draize.
Irritation from exposure was noted but effects were fully reversible by 2 days. The study authors reported a Draize score of 13 out of a possible 30, with full recovery at 2 days.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Justification for classification or non-classification
No classification is warranted according to CLP criteria.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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