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EC number: 202-844-7 | CAS number: 100-36-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance is corrosive to the skin and denaturates eye mucous membranes.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to BASF-internal standard, see details in the section "Any other information on materials and methods incl. tables".
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Mean body weights of the rabbits: 2.85 kg
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal served as control.
- Amount / concentration applied:
- ca. 1 mL
- Duration of treatment / exposure:
- 3 minutes
- Observation period:
- 8 days
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24 - 48 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: parchment-like necrosis (comprehensive)
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24 - 48 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks on result:
- other: comprehensive
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2
- Time point:
- other: 3 min
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: necrosis observed, overarching skin reaction
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2
- Time point:
- other: 3 min
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: overarching skin reaction
- Other effects:
- Pathology: The skin effects of the sacrificed animals were macroscopically confirmed.
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a skin irritation/corrosion study (BASF, 1980), 2 Vienna White rabbits were treated with undiluted test substance for 3 min using occlusive conditions. An application site of 2.5 cm² was covered with ca. 1 mL of the liquid test substance. The animals were observed for 8 days and skin changes were recorded daily. For a final evaluation, the findings from 24 and 48 hours from the raw data were taken into account on a mean basis (erythema score, edema score). The application for 3 min evoked after 3 min strong skin reactions and caused after 24 hours leathery-like necrosis in both animals. Parchment-like necrosis was observed after 8 days. This study is classified as acceptable. It generally satisfies the guideline requirements for OECD 404.
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to BASF-internal standard, see details in the section "Any other information on materials and methods incl. tables".
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- Mean body weights: 2.99 kg
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin of the same animal
- Amount / concentration applied:
- ca. 1 mL
- Duration of treatment / exposure:
- 20 h
- Observation period:
- 8 d
- Number of animals:
- 2
- Details on study design:
- Application area: 2.5 x 2.5 cm
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (incubation time: 5, 15; skin at the back)
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- other: after 8 days: severe, not relocatable necrosis
- Remarks on result:
- other: at the edge, in general leathery necrosis
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (incubation time: 20 h; skin at the back)
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days severe, not relocatable necrosis
- Remarks on result:
- other: at the edge, in general leathery necrosis
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- (incubation time: 1 min; skin at the back)
- Time point:
- other: 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days, necrosis still present
- Remarks on result:
- other: at the edge (incl. bleedings), in general necrosis
- Interpretation of results:
- highly corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Executive summary:
In a skin irritation/corrosion study (BASF, 1969), 2 Vienna White rabbits were treated with undiluted test substance for 1, 5, 15 min or 20 hours using occlusive conditions.An application site of 2.5 cm² was covered with ca. 1 mL of the liquid test substance.The animals were observed for 8 days and skin changes were recorded. For a final evaluation, the findings from 24 hours from the raw data were taken into account on a mean basis (erythema score, edema score). After application for 1 min leathery-like necrosis in both animals was observed after 24 hours. Severe, not relocatable necrosis was observed after 8 days.This study is classified as acceptable. It generally satisfies the guideline requirements for OECD 404.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not specified
- Principles of method if other than guideline:
- According to BASF-internal standard, see details in remarks on material and methods.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: he adjacent eye served as saline control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 50 µL - Duration of treatment / exposure:
- Single application
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- 50 µL of the test substance were applied to the conjunctival sac of one eye in 2 animals. The animals were observed after 10 min, 1 and 3 hours on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours as specified in OECD Guideline 405. The report describes findings after 1 and 24 hours and at the end of the observation period.
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: within few minutes
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: Reaction observed shortly after instillation.
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Executive summary:
In this acute eye irritation/corrosion study (BASF, 1969), the eyes of 2 Vienna White rabbits were exposed by application of 50 µL undiluted test substance into the conjunctival sac. The animals were observed after 10 min, 1 and 3 hours on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours. Overall, the treatment caused corrosion of the eye mucous membranes within 1 hour.Thus, the test substance was graded as corrosive under the conditions of this study. This study is classified as acceptable. It satisfies the requirements of OECD test guideline 405.
Reference
Already after a few minutes of the test substance instillation, corrosion of the eyes was observed.
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
In a skin irritation/corrosion study (BASF, 1980), 2 Vienna White rabbits were treated with undiluted test substance for 3 min using occlusive conditions. An application site of 2.5 cm² was covered with ca. 1 mL of the liquid test substance. The animals were observed for 8 days and skin changes were recorded daily. For a final evaluation, the findings from 24 and 48 hours from the raw data were taken into account on a mean basis (erythema score, edema score). The application for 3 min evoked after 3 min strong skin reactions and caused after 24 hours leathery-like necrosis in both animals. Parchment-like necrosis was observed after 8 days. This study is classified as acceptable. It generally satisfies the guideline requirements for OECD 404.
In a further skin irritation/corrosion study (BASF, 1969), 2 Vienna White rabbits were treated with undiluted test substance for 1, 5, 15 min or 20 hours using occlusive conditions. An application site of 2.5 cm² was covered with ca. 1 mL of the liquid test substance. The animals were observed for 8 days and skin changes were recorded. For a final evaluation, the findings from 24 hours from the raw data were taken into account on a mean basis (erythema score, edema score). After application for 1 min leathery-like necrosis in both animals was observed after 24 hours. Severe, not relocatable necrosis was observed after 8 days. This study is classified as acceptable. It generally satisfies the guideline requirements for OECD 404.
Based on observed corrosive effects, the substance has to be judged as highly corrosive to skin.
Eye irritation
In an acute eye irritation/corrosion study (BASF, 1969), the eyes of 2 Vienna White rabbits were exposed by application of 50 µL undiluted test substance into the conjunctival sac. The animals were observed after 10 min, 1 and 3 hours on the day of treatment and up to 8 days afterwards. The eyes were not washed out after 24 hours. Overall, the treatment caused corrosion of the eye mucous membranes within 1 hour. Thus, the test substance was graded as corrosive under the conditions of this study. This study is classified as acceptable. It satisfies the requirements of OECD test guideline 405.
Justification for classification or non-classification
Based on the results for skin irritation (corrosive) and for eye irritation, the test substance is classified for skin irritation/corrosion as follows:
Classification, Labelling, and Packaging Regulation (EC) No 1272/2008
The available experimental test data are reliable and suitable for classification purposes under Regulation 1272/2008 (CLP). As a result the substance is considered to be classified for skin or eye irritation under Regulation (EC) No 1272/2008, as amended for the sixth time in Regulation (EC) No 605/2014, as follows:
Cat. 1A, H314, causes severe skin burns and eye damage; Cat. 1, H318, causes serious eye damage.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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