Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 280-445-7 | CAS number: 83411-71-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From November 4th,1981 to April 22nd, 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no certificate of analysis and no data on the animal environmental conditions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- : no certificate of analysis, no data on the animal environmental conditions (temperature, humidity, air change)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- EC Number:
- 280-445-7
- EC Name:
- Bis(2,4,4-trimethylpentyl)phosphinic acid
- Cas Number:
- 83411-71-6
- Molecular formula:
- C16H35O2P
- IUPAC Name:
- bis(2,4,4-trimethylpentyl)phosphinic acid
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Breeding Laboratories, Inc., Portage, Michigan and Kingston, NY, USA
- Age at study initiation: no data
- Weight at study initiation: from 193.82 to 229.44 g
- Fasting period before study: yes, 24h prior to oral administration of test substance
- Housing: individually housed in wire-bottomed cages suspended above the droppings.
- Diet (e.g. ad libitum): Purina Certified Rodent Chow 5002, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: yes for 6 to 20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 6.63 ml/kg
- Doses:
- range finding study: 2.5; 3.5; 6.5; 7.5 g/kg bw
main test: 2.5; 3.5; 4.0; 5.0; 6.5 g/kg bw - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation twice daily, weighing on days -1; 0; 1; 2; 3; 6; 10 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, gross necropsy of visceral and thoracic cavity - Statistics:
- The Litchfield and Wilcoxon method was used to calculate the LD50
Results and discussion
- Preliminary study:
- at 2.5 g/kg bw: 2/4 anaimals died on day 1
at 3.5 g/kg bw: 1/4 animals died on day 1
at 6.5 g/kg bw: 4/4 animals died on day 1
at 7.5 g/kg bw: 3/4 animals died on days 1, 2 and 3
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 719 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 5 037 - <= 6 494
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 947 - <= 6 870
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 444 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 3 070 - <= 9 653
- Remarks on result:
- other: This does not include females died at 4.0 g/kg due to the dosing technique
- Mortality:
- 2.5 g/kg bw: 2/10 (day 3 and 6)
3.0 g/kg bw: 0/10
4.0 g/kg bw: 5/10 (4 females died on day 0. It appeared to be related to dosing technique. One male died on day 1)
5.0 g/kg bw: 4/10 (day 1, 2 and 6)
6.5 g/kg bw: 8/10 (day 1 and 2) - Clinical signs:
- other: Signs of systemic toxicity were observed 30 min after dosing at all dose levels. Reactions ranged from lethargy, bodies cool to touch, red material round mouth/nose, loose feces and fecal stains to ataxia and inactivity. The severity and incidence of reac
- Gross pathology:
- Positive gross pathologic findings were observed at all dose levels : gastrointestinal hemorrhage or appeared reddened, thickened area of stomach, intestines mucoid, intestine empty (at 6.5 g/kg bw dose level only).
Any other information on results incl. tables
Mortality after an oral administration of the substance
Dose (mg/kg) |
Mortality (# dead/total) |
Time range of death |
||
Male |
Female |
Combined |
||
2500 |
0/5 |
2/5 |
2/10 |
Day 3 and 6 |
3500 |
0/5 |
0/5 |
0/10 |
- |
4000 |
0/5 |
5/5 |
5/10 |
Day 0 (4 females died due to dosing technique), Day 1 (1 female) |
5000 |
1/5 |
3/5 |
4/10 |
Day 2 (1 female), Day 2 (1 male and 1 female), Day 10 (1 female) |
6000 |
4/5 |
4/5 |
8/10 |
Day 1 (4 males and 3 females), Day 2 (1 female) |
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified as harmful or toxic according to the CLP Regulation (EC) No.1272/2008
- Conclusions:
- LD50 (rat, male and female) = 5444 mg/kg bw
- Executive summary:
In an acute oral toxicity study, performed similarly to the OECD guideline No. 401, and in compliance with the GLP, groups of (SD) male and female rats (5 animals/sex/dose) were given a single oral dose (by gavage) of undiluted test substance.
The initial study was conducted with one dose level of 5000 mg/kg bw with ten rats. As 4/10 rats died, a range-finding study at doses of 2500; 3500; 6500 and 7500 mg/kg bw was performed. Death was observed at any dose levels. In the main study, the rats were administered by gavage the test substance at doses of 2500; 3500; 4000; 5000 and 6500 mg/kg bw. Clinical signs, mortality and body weight gain were checked for a period of up to 14 days.
Death is observed at all dose levels except at 3500 mg/kg bw. Signs of systemic toxicity were observed 30 min after dosing at all dose levels. Reactions ranged from lethargy, bodies cool to touch, red material round mouth and nose, loose feces and fecal stains to ataxia and inactivity. The severity and incidence of reactions increased with dose level. Furthermore, the mean bodyweight appeared to be decreased for the found dead animals. Positive gross pathologic findings were observed at all dose levels: gastrointestinal hemorrhage or appeared reddened, thickened area of stomach, intestines mucoid, intestine empty (at 6500 mg/kg bw dose level only).
Oral LD50in rats (male and female) = 5444 mg/kg bw
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.