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EC number: 600-026-8 | CAS number: 1000817-22-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
NOAEL systemic toxicity: 1000 mg/kg bw (highest dose tested, OECD 407, BASF SE 2010)
NOAEL local effects: 300 mg/kg bw (OECD 407, BASF SE, 2010)
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
The test substance was administered for 4 weeks daily by gavage to male and female Wistar rats at dose levels of 0, 100, 300 and 1000 mg/kg bw/d (test groups 0-3) according to OECD 407 guideline (BASF SE, 2010). Drinking water was used as vehicle control and vehicle for the test substance.
Regarding clinical examinations, signs of general systemic toxicity were not observed up to a dose level of 1000 mg/kg bw/d.
Salivation was seen after dosing in all rats of test group 3 (1000 mg/kg bw/d), in all male and 3 female animals of test group 2 (300 mg/kg bw/d) and in 1 male animal of test group 1 (100 mg/kg bw/d). From the temporary, short appearance immediately after dosing it is most likely, that this finding was induced by a bad taste of the test substance or local affection of the upper digestive tract. This finding was not considered to be an adverse and toxicologically relevant effect.
Concerning clinical pathology no treatment-related, adverse effects were observed up to a dose of 1000 mg/kg bw/d.
Regarding pathology, the target organ was the forestomach. In 3 different male and 1 female animal of test group 3 (1000 mg/kg bw/d) a focal squamous hyperplasia (1 male), an erosion or ulcer occurred in the region of margo plicatus (1 male and 1 female) and a minimal focal inflammation in the region of margo plicatus (1 male) were noted. All these findings were related to treatment and were considered to be adverse. Again, these findings were most likely related to the irritating potential as the test substance was directly administered into the forestomach by gavage with the consequence of a local irritation.
All further findings occurred either singly or were biologically equally distributed over the control group 0 and the treatment groups 1-3 (100, 300 and 1000 mg/kg bw/d). They were considered to be incidental or spontaneous in origin and without any relation to treatment.
The NOAEL for systemic toxicity was 1000 mg/kg bw., the NOAEL for local effects in the forestomach was 300 mg/kg bw.
Justification for classification or non-classification
Besides local irritation in the forestomach, no other effects relevant to human health were observed. Therefore no classification and labeling is required according to 67/548/EWG and 1272/2008/EG (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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