Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-557-2 | CAS number: 122-60-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable study which meets basic scientific principles
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Dosimetry of glycidyl ethers in mice by quantification of haemoglobin adducts
- Author:
- Perez HL, Plna K, Ostermann-Golkar S
- Year:
- 1 997
- Bibliographic source:
- Chemico-Biological Interactions 103, 1-16
- Reference Type:
- secondary source
- Title:
- Epoxy Compounds
- Author:
- Waechter JM et al.
- Year:
- 2 001
- Bibliographic source:
- Patty´s Toxicology, fifth edition, vol. 6, 1063-1085
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- N-alkyl Edman method (not further specified)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl glycidyl ether
- IUPAC Name:
- Phenyl glycidyl ether
- Details on test material:
- - Name of test material (as cited in study report): Phenyl glycidyl ether
- Purity: 99 %
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: C3H/Hej mice
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 30 g
- Diet (e.g. ad libitum): standard pellet diet ad libitum
- Water (e.g. ad libitum): ad libitum
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- other: Tricaprylin
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: The glycidyl ethers were dissolved in tricaprylin to give 40 mg/ml.
- Duration and frequency of treatment / exposure:
- once in 24 hours
Doses / concentrations
- Remarks:
- Doses / Concentrations:
4 mg/mouse
- No. of animals per sex per dose / concentration:
- 3
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Control animals were administered 0.1 ml tricaprylin. The animals of the test and control group were sacrificed 24 h after injection and blood was collected in heparinsed tubes. The control animals were killed at the same time.
- Isolation of globin
- Derivatisation of globin samples
- Calibration
- Analysis of PFPTHs with GC/MS and GC/MS-MS
Results and discussion
Any other information on results incl. tables
- Characterisation of the pentafluorophenylthiohydantoin derivatives of the glycidyl ether-valine adducts by GC-MS: adduct formation mainly occurs through reaction of valine with the chiral beta-carbon of the glycidyl ethers.
- Haemoglobin adduct levels in glycidyl ether-treated mice: The HBI (haemoglobin binding index)-values were used to calculate the dose in erythrocytes resulting from 1 mmol/kg body weight of the various glycidyl ethers. The doses calculated for the glycidyl ethers are somewhat lower than that of other substances like propylene oxide suggesting a rapid detoxification of the compounds in the mouse. Therefore the test substance appears to be more rapidly detoxified.
- HBI of the test substance = 1.3 pmol/g globin.
.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)