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EC number: 222-374-6 | CAS number: 3452-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Two developmental/reproductive screening studies were available for linear alpha olefins (a 41-55 day study with hex-1-ene (Daniel, 1999) and a 43-51 day study with tetradec-1-ene (Daniel, 1999), both of which reported no treatment-related adverse effects on fertility and developmental parameters at the highest dose tested (1000 mg/kg bw/day). Results from developmental/reproductive screening studies conducted on isomerised olefin substances such as octadecene (Thorsrud, 2003) and C6, alkenes (Thorsrud, 2003) were also negative for effects on fertility and development. The weight of evidence presented by these studies suggests that higher olefin substances, as a group, are unlikely to present a significant hazard potential to fertility and development. However, these studies do not meet standard REACH information requirements for this endpoint since the studies do not fully assess all phases of the reproductive cycle (e. g. oestrus cyclicity, sperm quality, post weaning development, maturation and the reproductive capacity of the offspring). Further testing on oct-1-ene (CAS RN 111-66 -0), a linear alpha olefin, has been proposed to address these outstanding toxicological endpoint data gaps for all higher olefins.
Workers
A worker-DNELlong-term for dermal route-systemicand worker-DNELlong term for inhalation route-systemic were not derived for linear alpha olefins because no adverse findings relevant to human health risk assessment were found in a 90-day inhalation repeated dose study with hex-1-ene (Bennick et al., 1984) and a combined repeated dose/ reproductive/developmental screening study with tetradec-1-ene (Daniel, 1995). No relevant adverse effects were observed at the highest dose tested in each study (3000 ppm corresponding with 10.3 mg/L hex-1-ene and 1000 mg/kg bw/day tetradec-1-ene, respectively). Results from an additional good quality and high reliability 90-day repeated dose study with multiple carbon number isomerised olefin, alkenes, C20-24 (Brooker, 1999), also reported no adverse findings relevant to human health at the limit dose of 1000 mg/kg bw/day. The weight of evidence presented by these study results indicates that higher olefins, as a class, possess an inherently low hazard potential with regard to human health. Therefore, derivation of long-term DNELs is unnecessary. A worker-DNELlong-term for oral route-systemicwas not calculated for linear alpha olefins because oral exposure to these substances was not a relevant route of exposure for a worker population.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
General population
General population DNELs for acute effects were not derived because no relevant hazard was apparent from the available toxicological data.
A general population-DNELlong-term for oral route-systemic, general population-DNELlong-term for dermal route-systemic, and general population-DNELlong term for inhalation route-systemicwere not derived for linear alpha olefins because no adverse findings relevant to human health risk assessment were found in a 90-day inhalation repeated dose study with hex-1-ene (Bennick et al., 1984) and a combined repeated dose/ reproductive/developmental screening study with tetradec-1-ene (Daniel, 1995). No relevant adverse effects were observed at the highest dose tested in each study (3000 ppm corresponding with 10.3 mg/L hex-1-ene and 1000 mg/kg bw/day tetradec-1-ene, respectively). Results from an additional good quality and high reliability 90-day repeated dose study with multiple carbon number isomerised olefins, alkenes, C20-24 (Brooker, 1999), also reported no adverse findings relevant to human health at the limit dose of 1000 mg/kg bw/day. The weight of evidence presented by these study results indicates that higher olefins, as a class, possess an inherently low hazard potential with regard to human health. Therefore, derivation of long-term DNELs is unnecessary.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.