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Diss Factsheets
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EC number: 233-116-7 | CAS number: 10038-98-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Objective of study:
- toxicokinetics
- Principles of method if other than guideline:
- Absorption, transport, distribution, storage and excretion of inorganic germanium in albino rats
- GLP compliance:
- not specified
- Radiolabelling:
- no
- Species:
- rat
- Strain:
- other: albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no information
- Age at study initiation: no information
- Weight at study initiation: no information
- Fasting period before study: no information
- Housing: well ventilated cages
- Individual metabolism cages: no information
- Diet (e.g. ad libitum): no information
- Water (e.g. ad libitum): no information
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS : no information
- Temperature (°C):
- Humidity (%):
- Air changes (per hr):
- Photoperiod (hrs dark / hrs light): - Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- Doses / Concentrations:
10mg - Control animals:
- not specified
- Type:
- absorption
- Results:
- rapid absorption after gavage (73.6% after 4h and 96.4% after 8h)
- Type:
- distribution
- Results:
- uniformly distributed between erythrocytes and plasma (2:3) and not bound to plasma proteins. Not deposited selectively but widely distributed among all the organs.
- Type:
- excretion
- Results:
- rapidly excreted via the urine and feces, kidney being the main excretory organ
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
Germanium is relatively inert metabolically and are consonant with its remarkably low toxicity - Executive summary:
Metabolic studies have been conducted of the absorption, transport, distribution, storage and excretion of inorganic germanium (GeO2) in albino rats.
The analytical data demonstrate that germanium is rapidly absorbed after oral, subcutaneous, intramuscular or intraperitoneal administration.
When injected directly into the systemic circulation or absorbed following oral or parenteral administration, it is transported unbound by plasma proteins and is rapidly eliminated from the blood stream.
Germanium is not deposited selectively but is widely distributed among all the organs. It is not retained or stored by any tissue even after many weekly doses, but is rapidly excreted via the urine and feces, the kidney bein the main excretory organ.
Reference
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 73.6
Additional information
GeCl4 spontaneously hydrolysis in contact with water to HCl and GeO2. The key study on GeO2 demonstrates that germanium is rapidly absorbed after oral administration.
When absorbed following oral administration, it is transported unbound by plasma proteins and is rapidly eliminated from the blood stream.
Germanium is not deposited selectively but is widely distributed among all the organs. It is not retained or stored by any tissue even after many weekly doses, but is rapidly excreted via the urine and feces, the kidney being the main excretory organ.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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