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EC number: 412-720-6 | CAS number: 156653-67-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 07 April 1993 to 20 April 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to EU test guidance in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Details on test material:
- See below
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
Not applicable. - Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Sample Preparation
Direct injection of the test solutions was possible - Buffers:
- pH 4 buffer solution (citric acid - monohydrate)
pH 7 buffer solution (potassiumdihydrogen phosphate) - Details on test conditions:
- Choice of Concentration
The optimal concentration of test substance required for the HPLC analysis is about 200 mg/l. This value is less than the solubility in water (217 g/l) and thus satisfies the requirements of the guidelines.
Preparation of Test Samples
Solutions of the test substance were prepared by weighing ca. 20 mg of the test substance in a 100 ml volumetric flasks and dissolving in the relevant buffer.
The time between dissolution of the test sample and placing it into the thermostatic water bath (thermostated at the required hydrolysis temperature) was kept as short as possible.
Hydrolysis Test Procedure
The flask containing the hydrolysis mixture was placed in a water bath set thermostatically at the prescribed temperature for the time specified. Thereafter it was cooled immediately. A sample was taken and HPLC analysis of the unhydrolysed test substance (main compound) performed without delay.
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50
- Initial conc. measured:
- 195.5 mg/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 206.7 mg/L
- Duration:
- 22.67 h
- pH:
- 7
- Temp.:
- 50
- Initial conc. measured:
- 188.46 mg/L
- Duration:
- 5.03 h
- pH:
- 7
- Temp.:
- 60
- Initial conc. measured:
- 202.48 mg/L
- Duration:
- 1.97 h
- pH:
- 7
- Temp.:
- 70
- Initial conc. measured:
- 197.42 mg/L
- Number of replicates:
- 2
- Positive controls:
- not specified
- Negative controls:
- not specified
- Statistical methods:
- The calculation standards used in the tests were freshly prepared solutions of the test substance in the relevant buffer.
The initial concentrations (c(0)) of the test substance were calculated from the sample weights.
c(t) =
The concentrations during the test process (c(t)) were calculated from the HPLC peak areas of the main component using the formula:
c(t) = c(Standard) * Peak Area(Sample) / Peak Area (Standard)
Results and discussion
- Preliminary study:
- The decomposition at pH 4 is less than 10 % after 5 days, thus making further tests unnecessary. The test substance may be considered hydrolytically stable at pH 4 according to the guideline. Therefore the half-life period, at 25 °C, may be estimated as greater than one year. The preliminary tests at pH 7 indicate that an examination of the linearity of the hydrolysis kinetics.
- Test performance:
- The test performed within the expected parameters. See below for results table. The substance is stable to hydrolysis at pH4, hydrolyses slowly at pH7 and rapidly at pH9.
- Transformation products:
- not measured
- Details on hydrolysis and appearance of transformation product(s):
- Not measured
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Remarks on result:
- other: prelimary test
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 10.4 d
- Remarks on result:
- other: extrapolated from the results of test 1 and 3
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 1 d
- Remarks on result:
- other: derived from hydrolysis investigations with substances of the same class
- Details on results:
- Test 1 showed an approximately linear relationship between log(c(t)/c(0)) and t. As a consequence the analyses in the guidelines described as Test 3 were performed using test temperatures of 60 °C and 70 °C.
The reaction rate constant and the resulting half-life period at 25 °C and pH 7 are determined by extrapolating the results of tests 1 and 3 using the Arrhenius equation.
Any other information on results incl. tables
Results of Analyses performed at pH 7
Temp. (⁰C) |
Kobs(h-1) |
t½(h) |
t½(d) |
70 |
0.5728 |
1.2 |
0.1 |
60 |
0.1840 |
3.8 |
0.2 |
50 |
0.0651 |
10.7 |
0.4 |
25 |
0.0028 |
249.4 |
10.4 |
Applicant's summary and conclusion
- Conclusions:
- The half-life periods at 25 °C of Reaktiv-Gelb F-66923 FW are:
> 1 year at pH 4 (preliminary test)
10.4 d at pH 7 (extrapolated from the results of test 1 and 3)
< 1 d at pH 9 (derived from hydrolysis investigations with substances of the same class) - Executive summary:
The objective of this study was the determination of the abiotic degradation of the test substance (the main compound), i.e. the determination of the hydrolysis rate as a function of the pH-value according to 84/449/EWG. Study conducted in compliance with GLP.
The decomposition at pH 4 is less than 10% after 5 days, thus making further tests unnecessary. The test substance may be considered hydrolytically stable at pH 4 according to the guideline. Therefore the half-life period, at 25°C, may be estimated as greater than one year. The preliminary testsat pH 7 indicate that an examination of the linearity of the hydrolysis kinetics
The half-life periods at 25 °Cof Reaktiv-Gelb F-66923 FW are:
>1year at pH4 (preliminary test)
10.4d at pH7 (extrapolated from the results of test 1 and 3)
<1d at pH9 (derived from hydrolysis investigations with substances of the same class)
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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