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Diss Factsheets
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EC number: 230-745-9 | CAS number: 7300-34-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
- Report date:
- 1972
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- BASF test: only 8 das observation period; eyes were not washed out after 24 h
- GLP compliance:
- no
Test material
- Reference substance name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- EC Number:
- 230-745-9
- EC Name:
- 3,3'-[butane-1,4-diylbis(oxy)]bispropanamine
- Cas Number:
- 7300-34-7
- Molecular formula:
- C10H24N2O2
- IUPAC Name:
- 3-[4-(3-aminopropoxy)butoxy]propan-1-amine
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): Butandiol-di(aminopropyl)-ether
- Physical state: liquid
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- 50 µl of the test item were applied to the right eye; the left eye serves as control and was treated with 50 µl NaCl; the test substance was not washed out after 24 h
- Duration of treatment / exposure:
- The test item was not washed out and remained in the eye for the entire course of the experiment
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: cannot be determined at day 8 due to severe corrosion
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Max. score:
- 3
- Remarks on result:
- other: strong erytheme at day 8
- Irritant / corrosive response data:
- Test item application had severe effects on rabbit eyes; after 8 days, severe pus formation can be observed accompanied by staphylom and scar formation, severe erythema and marked chemosis. Pus formation was observed during the entire course of the experiment; soft necosis was observed 24 and 48 and hard necrosis 72 h following test item application; due to the severe lesions, redness of the conjunctivae could not be assessed.
Any other information on results incl. tables
Irritation scores:
Time |
Cornea |
Conjuctivae |
Iris |
Chemosis |
||||
|
A1 |
A2 |
A1 |
A2 |
A1 |
A2 |
A1 |
A2 |
24 h |
3 |
3 |
n.a. |
n.a. |
|
|
2 |
3-4 |
48 h |
3 |
3 |
n.a. |
n.a. |
2 |
|
3-4 |
3-4 |
72 h |
3 |
3 |
n.a. |
n.a. |
2 |
|
2 |
3-4 |
8 d |
|
|
2 |
2 |
2 |
|
2 |
2 |
A1/A2: Animal 1/Animal 2
n.a.: not assessable
No data concerning iritis for animal 2
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
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