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Diss Factsheets
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EC number: 612-179-8 | CAS number: 61597-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 3.11 µg/L
- Assessment factor:
- 1 000
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 31.1 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 0.311 µg/L
- Assessment factor:
- 10 000
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 6.5 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 0.36 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- PNEC sediment (marine water)
- PNEC value:
- 0.036 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.07 mg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- PNEC oral
- PNEC value:
- 365 mg/kg food
Additional information
The freshwater alga represents the most sensitive species with regard to acute exposure to the substance. The hazard assessment therefore is based on the effect levels of the algal study and the PNECs aqua will be derived from the ErC50 value of 3.11 mg/L. PNEC sediment and PNEC soil were being derived using the equilibrium-partitioning method. A valid respiration inhibition test is available, the EC50 value was 650 mg/L after 3 hours and this is used in the hazard assessment. The PNEC oral is derived from the NOAEL of 548 mg/kg/day observed in a chronic oral toxicity study with the substance DL menthol.
Conclusion on classification
Acute aquatic toxicity:
Freshwater algae represent the most sensitive species with regard to acute exposure to the substance with an ErC50 value of 3.11 mg/L (as derived from the study with read across substance menthyl acetate). Being above the trigger level for acute aquatic toxicity classification of 1.0 mg/L, no classification applicable according to CLP Regulation (Regulation (EC) No 1272/2008) or according to DSD Regulation (Council Directive 2001/59/EC (28th ATP of Directive 67/548/EEC)).
Chronic aquatic toxicity - CLP:
Since the 2nd Amendment of the CLP Regulation, data from long-term studies are preferred over data from short term studies. The only aquatic toxicity long-term study available is the algal growth inhibition study with read across substance menthyl acetate. The ErC10 and NOEC values were determined to 0.7 mg/L and 0.18 mg/L menthyl lactate, respectively. Based on the 2nd Amendment of the CLP Regulation, Table 4.10, classification as chronic aquatic toxicity category 3 is applicable, as the EC10 / NOEC are within the range 0.1 - 1.0 mg/L and the substance is rapidly degradable. The acute L(E)50 values for fish, daphnia and algae are not triggering chronic aquatic toxicity classification as the substance is rapidly degradable and has a log Kow < 4.0.
Chronic aquatic toxicity - DSD:
In the DSD Regulation only data from acute aquatic toxicity studies have been considered for chronic aquatic toxicity classification.
Comparing the results from the acute aquatic toxicity studies, the freshwater algae was found to be the most sensitive organism with an EC50 of 3.11 mg/L (growth rate). As the EC50 therefore is within the range 1.0 - 10.0 mg/L, and the substance furthermore has a log Kow > 3.0, classification R51/53 is applicable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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