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EC number: 219-669-7 | CAS number: 2494-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 10. Feb 1988 - 11 Mar 1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2-[(p-aminophenyl)sulphonyl]ethyl hydrogensulphate
- EC Number:
- 219-669-7
- EC Name:
- 2-[(p-aminophenyl)sulphonyl]ethyl hydrogensulphate
- Cas Number:
- 2494-89-5
- Molecular formula:
- C8H11NO6S2
- IUPAC Name:
- [2-(4-aminobenzenesulfonyl)ethoxy]sulfonic acid
- Details on test material:
- - Name of test material (as cited in study report): p-Base-Ester
Batch no.: Op. 1345/1987
CoA: 65 signed 18. January 1987
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
- Details on sampling:
- - Concentrations: 125 mg/L (nominal); 101.3 mg/L (measured)
180 mg/L (nominal); 163.7 mg/L (measured)
250 mg/L (nominal); 159.7 mg/L (measured)
- Sampling method: mid of the tank
- Sampling time: 48 h and 96 h
- Sampling volume: ca. 100 mL
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- TS was diluted in dilution water by Ultra-Turrax and ultra sonification and distributed evenly in the tank by means of a glass stirrer
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebrabärbling - Brachydanio rerio (Hamilton-Buchanan)
- Strain: Hamilton-Buchanan
- Source: Hoechst AG Eigenzucht der Gewebetoxikologie, Germany
- Date of eclosion: 15. Oct. 1987 - 24. Nov. 1987
- Delivery date:
- Study start: 29. Feb. 1988
- Study end: 11. Mar. 1988
- Length at study initiation (length definition, mean, range and SD): 2.7 to 3.2 cm; mean: 0.0 cm; SD: 0.14
- Weight at study initiation (mean and range, SD):
- Method of breeding:
- Feeding during test: twice per day
ACCLIMATION
- Acclimation period: at least 14 days
- Acclimation conditions:
- Dilution water (ISO/DIS 7346/1)
- 21 to 23°C
- >= 80% Oxygen saturation
- pH 8.3
- 12 hours illumination
- <= 1 g fish/liter
- Type and amount of food: Tetra Min, Tetra Werke, Melle
- Feeding frequency: twice/day
- Health during acclimation (any mortality observed): -
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 96 h
- Post exposure observation period:
- NA
Test conditions
- Hardness:
- no data
- Test temperature:
- Test Group: 21.9 to 22.2°C
Control Group: 21.6 to 22.2°C - pH:
- Test Group: 7.1 to 8.1
Control Group: 7.4 to 8.0 - Dissolved oxygen:
- Test Group: 7.2 to 9.2 mg/L
Control Group: 7.1 to 9.0 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Material, size, headspace, fill volume: Glass, 30x22x24 cm³, 10 liter
- Aeration: oxygen saturated water was used, no aeration during test
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): at least one
- No. of vessels per control (replicates): at least one
- No. of vessels per vehicle control (replicates): NA
- Biomass loading rate: <= 1 g fish/L water
TEST MEDIUM / WATER PARAMETERS
- Intervals of water quality measurement: 2-4, 24, 48, 72, 96 h
OTHER TEST CONDITIONS
- Adjustment of pH: 8.1
- Photoperiod: 12/12 h
- Light intensity: ca. 700 Lux
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : 2-4, 24, 48, 72, 96 h
mortality, appearence, behavior, necropsy - Reference substance (positive control):
- not required
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 125 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 150 mg/L
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 180 mg/L
- Details on results:
- - Behavioural abnormalities: At 180 and 250 mg/l less activity and other swimming position
- Observations on body length and weight: NA
- Other biological observations: At 250 mg/l gill covers standing away
- Mortality of control: no control
- Other adverse effects control: no control
- Abnormal responses: at 125 mg/l enhanced breathing rate and startle response
- Any observations (e.g. precipitation) that might cause a difference between measured and nominal values: little clouding at 125 mg/l. At 180 and 250 mg/l clouding and precipitation
- Effect concentrations exceeding solubility of substance in test medium: very little
- Other: no effects - Results with reference substance (positive control):
- NA
- Reported statistics and error estimates:
- NA
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- no mortality was observed after 96 hours exposure to 125 mg/L parabaseester
no mortality was observed after 48 hours exposure to 180 or 250 mg/L parabaseester
100% mortality was observed after 96 hours exposure to 180 or 250 mg/L parabaseester
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