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Reaction mass of (1RS,2RS,7SR,8RS,9E)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2RS,7SR,8RS,9Z)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10E)-10-Ethylidene-3-oxatricyclo[6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10Z)-10-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane
EC number: 941-194-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Performed under GLP and follows a method similar to an OECD guideline; limited test material characterisation.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Reaction mass of (1RS,2RS,7SR,8RS,9E)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2RS,7SR,8RS,9Z)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10E)-10-Ethylidene-3-oxatricyclo[6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10Z)-10-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane
- Molecular formula:
- C12H18O
- IUPAC Name:
- Reaction mass of (1RS,2RS,7SR,8RS,9E)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2RS,7SR,8RS,9Z)-9-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10E)-10-Ethylidene-3-oxatricyclo[6.2.1.0(2,7)] undecane and (1RS,2SR,7SR,8SR,10Z)-10-Ethylidene-3-oxatricyclo [6.2.1.0(2,7)] undecane
- Test material form:
- other: liquid
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: recognised animal supplier
- Age at study initiation: no data
- Weight at study initiation: 2 - 4 kg
- Housing: individually housed in wire mesh bottom cages.
- Diet (e.g. ad libitum): certified animal feed ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): not reported
- Humidity (%): not reported
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): undiluted - Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: dorsal surface
- Type of wrap if used: each test site was occluded with a one-inch square gauze patch. The trunk of each animal was then wrapped with an occlusive binder -this consisted of a layer of plastic wrap, a protective cloth and a stockinette sleeve all secured in place with masking tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The exposure sites were gently wiped with clean gauze to remove as much non-absorbed test article as possible.
- Time after start of exposure: 24h
SCORING SYSTEM: Draize scoring system.
Results and discussion
In vivo
Results
- Irritation parameter:
- other: mean primary irritation score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- 0.75
- Max. score:
- 8
- Reversibility:
- fully reversible
- Irritant / corrosive response data:
- All animals developed very slight to moderate erythema at the 24h observation period. By the 72h observation period these effects had fully reversed.
Any other information on results incl. tables
Table 1. Primary score irritation scores
Time | Skin | Rabbit | ||||||
1 | 2 | 3 | 4 | 5 | 6 | |||
Erythema and eschar formation | 24 | Intact | 2 | 1 | 1 | 2 | 2 | 1 |
72 | Intact | 0 | 0 | 0 | 0 | 0 | 0 | |
24 | Abraded | 2 | 1 | 1 | 2 | 2 | 1 | |
72 | Abraded | 0 | 0 | 0 | 0 | 0 | 0 | |
Total (a) | 4 | 2 | 2 | 4 | 4 | 2 | ||
Oedema formation | 24 | Intact | 0 | 0 | 0 | 0 | 0 | 0 |
72 | Intact | 0 | 0 | 0 | 0 | 0 | 0 | |
24 | Abraded | 0 | 0 | 0 | 0 | 0 | 0 | |
72 | Abraded | 0 | 0 | 0 | 0 | 0 | 0 | |
Total (b) | 0 | 0 | 0 | 0 | 0 | 0 | ||
Overall total (a + b) | 4 | 2 | 2 | 4 | 4 | 2 | ||
Individual animal scores | 1 | 0.5 | 0.5 | 1 | 1 | 0.5 | ||
Mean score | 0.75 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the authors report that the test material is slightly irritating to the skin of New Zealand White rabbits. However according to the CLP classification system, the test material is not considered to be irritating to skin.
- Executive summary:
The study was performed to assess the skin irritation potential of the test material in New Zealand White rabbits. The study was performed under GLP and followed a method similar to OECD guideline 404. A volume of 0.5 ml of undiluted test material was applied to each of 2 sites per rabbit. The test sites were separated by the spinal column. Prior to test article application, the test site on the right dorsal side was abraded with the tip of a 22 gauge hypodermic needle. The abrasions were 4 incisions made in cross hatch which penetrated the stratum corneum but did not disturb the derma and/or produce bleeding. Following application, each test site was occluded with a one-inch square gauze patch. The trunk of each animal was then wrapped with an occlusive dressing. At the 24h observation period, all animals developed very slight to moderate erythema; by the 72h observation period these effects had fully reversed. An overall mean primary irritation score was determined as 0.75. Under the conditions of this study, the authors report that the test material is slightly irritating to the skin of New Zealand White rabbits. However according to the CLP classification system, the test material is not considered to be irritating to skin.
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