2,2-dimethyloxirane

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1979 - 1980

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

Remarks:

; study performed prior to OECD TG 403

Principles of method if other than guideline:

Method: other: BASF-Test, see details in the section "Any other information on materials and methods incl. tables".

GLP compliance:

no

Remarks:

study was performed prior to GLP implementation

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2,2-dimethyloxirane

EC Number:

209-193-8

EC Name:

2,2-dimethyloxirane

Cas Number:

558-30-5

Molecular formula:

C4H8O

IUPAC Name:

2,2-dimethyloxirane

Details on test material:

Please refer to the section "confidential details on test material" below.

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: young adult (based on body weight)
- Weight at study initiation: 225 to 218 g (male), 185 - 198 g (female)
- Diet: H. EGGERSMANN KG, Germany

IN-LIFE DATES: From: 1979-03-19 To: 1979-04-03

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Animals were exposed by inhalation to a saturated vapor-air mixture of the test substance at 20 degrees centigrade

Analytical verification of test atmosphere concentrations:

no

Duration of exposure:

>= 3 - <= 25 min

Concentrations:

3 min: ca. 133394 ppm (approximately 400 mg/L)
10 min: ca. 225072 ppm (approximately 674 mg/L)
25 min: ca. 279998 ppm (approximately 839 mg/L)

No. of animals per sex per dose:

6 animals (3 min), 3 animals (10, 25 min)

Control animals:

no

Details on study design:

Please refer to details in the section "Any other information on materials and methods incl. tables".

Results and discussion

Mortality:

After 3 min 1/12, after 10 and 25 min 4/6 rats died.

Clinical signs:

other: - escape attempts - eyelid closure - salivation - intermittent respiration - gasping - discharge (eyes, nose) - ruffy fur - slight erythema (ears, extremities) - unsteady gait

Gross pathology:

Animals died during the study: heart - right-sided acute dilatation, acute hyperaemia; lung - edema
Animals sacrificed: organs without findings

Any other information on results incl. tables

Since test results depending on toxicity and volatility, conclusions on the acute inhalation toxicity are not possible.