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Diss Factsheets
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EC number: - | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 May 2008 and 13 June 2008
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted to GLP and in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not effect the quality of the relevant results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- The work described was performed in compliance with UK GLP standards (Schedule 1, Good Laboratory Practice Regulations 1999 (SI 1999/3106 as amended by SI 2004/0994)).
- Type of method:
- flask method
Test material
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 217 g/L
- Temp.:
- 20 °C
- pH:
- ca. 7.8
- Details on results:
- The water solubility of the test material has been determined to be 217 g/l of solution at 20.0 ± 0.5°C.
Any other information on results incl. tables
Preliminary test
Observations, concentrations and pH relating to the samples are shown in the following table:
Sample |
Concentration (% w/w) |
Observation |
pH |
1 |
9.1 (w/v) |
No excess of test material. |
6.5 |
2 |
20.0 |
Clear, colourless solution, with some test material undissolved. |
7.1 |
3 |
39.9 |
As for Sample 2, but more test material undissolved. |
7.1 |
4 |
60.0 |
As for Sample 3, but more test material undissolved. |
7.6 |
5 |
79.6 |
Wet powder. |
* |
The preliminary estimate of water solubility was between 9.1% w/v and 20.0% w/w of solution.
* not measured due to the nature of the sample
Definitive test
The absorbances relating to the standard and sample solutions are shown in the following table:
Solution |
Absorbance |
Standard 25.3 mg/l |
0.51712 |
Standard 25.4 mg/l |
0.52246 |
Matrix blank |
None detected |
Sample 1A1 |
0.43865 |
Sample 1B1 |
0.44734 |
Sample 2A1 |
0.44346 |
Sample 2B1 |
0.44939 |
Sample 3A1 |
0.44681 |
Sample 3B1 |
0.45306 |
The concentration (g/l) of test material in the sample solutions is shown in the following table:
Sample Number |
Time Shaken at ~ 30ºC (hours) |
Time Equilibrated at 20ºC (hours) |
Concentration (g/l) |
Solution pH |
1 |
24 |
24 |
216 |
7.1 |
2 |
48 |
24 |
217 |
7.8 |
3 |
72 |
24 |
219 |
7.5 |
Mean concentration: 217 g/l at
20.0 ± 0.5ºC
Range: 216 to 219 g/L
Validation
The linearity of the detector response with respect to concentration was assessed over the nominal concentration range of 0 to 50 mg/L. This was satisfactory with a correlation coefficient of 1.00 being obtained.
Discussion
Due to the high saturation level noted in the preliminary test, it was not possible to prepare samples at five times the saturation level as recommended in the guideline. However, the samples did indicate excess undissolved test material.
Conclusion
The water solubility of the test material has been determined to be 217 g/L of solution at 20.0 ± 0.5°C.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be 217 g/l of solution at 20.0 ± 0.5°C. - Executive summary:
The determination for substance NDS-Li in project number 1307 -0447 was carried out using the flask method, Method A6 of Commission Directive 92/69/EEC (which constitutes Annex V of Council Directive 67/548/EEC). The water solubility of the test material has been determined to be 217 g/l of solution at 20.0 ± 0.5°C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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