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Diss Factsheets
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EC number: 939-946-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011-11-09 to 2011-11-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted in compliance with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive and done to a valid guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- only single dose used
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: EC 440/2008
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- reaction mass of (3R,5R)-3-chloro-5-(trichloromethyl)cyclopentene and (3S,5S)-3-chloro-5-(trichloromethyl)cyclopentene and (3R,4R)-3-chloro-4-(trichloromethyl)cyclopentene and (3S,4S)-3-chloro-4-(trichloromethyl)cyclopentene
- EC Number:
- 939-946-2
- Molecular formula:
- C6H6Cl4
- IUPAC Name:
- reaction mass of (3R,5R)-3-chloro-5-(trichloromethyl)cyclopentene and (3S,5S)-3-chloro-5-(trichloromethyl)cyclopentene and (3R,4R)-3-chloro-4-(trichloromethyl)cyclopentene and (3S,4S)-3-chloro-4-(trichloromethyl)cyclopentene
- Test material form:
- other: Dark Brown Liquid
Constituent 1
- Specific details on test material used for the study:
- EC Number: 939-946-2
Test animals
- Species:
- rat
- Strain:
- other: CRL:(W1) BR Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Species and strain: CRL:(WI) BRWistar rats
Hygienic level at arrival: SPF
Hygienic level during the study: Standard housing conditions
Justification of strain: Recognized by international guidelines as a recommended test system
Number of animals: 5 animals/sex
Sex: Male and female, female rats were nulliparous and non- pregnant
Age of animals: Young adult rats
Body weight range
at dosing: Between 207 g and 256 g
Acclimatization time: 6 days
Husbandry
Animal health: Only healthy animals were used for the study. The veterinarian certified the health status.
Room-Box: 242/1
Housing: Individual caging
Cage type: Type II. polypropylene/polycarbonate
Bedding: Laboratory bedding was available to animals during the study
Light: 12 hours daily, from 6.00 a.m. to 6.00 p.m.
Temperature: 22 ± 3 °C
Relative humidity: 30 - 70 %
Ventilation: 15 - 20 air exchanges per hour
Enrichment: Rodents are housed with deep wood sawdust bedding to allow digging and other normal rodent activities.
The temperature and relative humidity were recorded twice daily during the study.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- not specified
- Details on dermal exposure:
- The backs of the animals were shaven (approximately 10% area of the total body surface) approximately 24 hours prior to treatment. Only those animals without injury or irritation on the skin were used in the test.
On test day 0, the test item was applied at a single dose of 2000 mg/kg body weight applied uniformly over the skin and remained on the skin throughout a 24- hour exposure period. Sterile gauze pads were placed on the skin of rats at the site of application. These gauze pads were kept in contact with the skin by a patch with adhesive hypoallergenic plaster. The entire trunk of the animal was then wrapped with semi occlusive plastic wrap for 24 hours. At the end of the exposure period, residual test item was removed, using body temperature water. - Duration of exposure:
- 24 hours
- Doses:
- single dose 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- Single dermal semiocclusive dose at 2000 mg/kg to a group of 5 male and 5 female rats for a 24 hour exposure period.
- Statistics:
- No specific statistics used
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical signs observed
- Gross pathology:
- No treatement related macroscopic findings were observed
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- The median lethal dose after single dermal administration was found to be greater than 2000 mg/kg bw in male and female CRL:(WI) BR Wistar rats.
The study is considered to be relevant, reliable, adequate for risk assessment, and adequate for classification purposes. - Executive summary:
A single administration at a dose of 2000 mg/kg body weight was applied dermally to 5 male and 5 female CRL:(WI) BR Wistar rats, followed by a 14-day observation period. The test item was applied as supplied by the Sponsor. The application period was 24 hours.
Clinical observations were assessed in all animals at 1 and 5 hours after dosing and daily for 14 days thereafter. Body weight was measured prior to dosing on Day 0 and on Days 7 and 14. All animals were euthanized and subjected to a gross macroscopic examination at the end of the 14-day observation period (Day 14).
Results
No mortality occurred during the study.
No adverse clinical signs were observed after treatment with the test item or during the 14 day observation period. Erythema was noted on the skin in all animals after dosing from Day 1 up until Day 2 (for one animal), Day 3 for 7 animals, Day 4 for one animal and Day 5 in another.
There were no effects on body weight or body weight gain during the observation period.
There were no treatment-related observations at necropsy.
Conclusion
The median lethal dose of the substance after a single dermal administration was found to be greater than 2000 mg/kg bw in male and female CRL:(WI) BR Wistar rats.
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