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Diss Factsheets
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EC number: 614-295-4 | CAS number: 68131-40-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. CALCULATION: EC10 = 10-0.280 log Kow+1.90 (Boeije et al 2006)
2. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
- Defined endpoint: EC10
- Unambiguous algorithm: 10-0.280 log Kow+1.90
- Defined domain of applicability: the training set includes alcohol ethoxylate mixtures (C9-11AE6, C12-13AE6.5, C12-15AE6, C12-15AE9, C13-15AE5 or C14-15AE7) and with the range of Log Kow is 3.65 to 5.91 (calculation based on Leo and Hansh, 1979)
- Appropriate measures of goodness-of-fit and robustness and predictivity:
- Mechanistic interpretation:based on nonspecific membrane disruption being the mode of action for all AE toxicity, which means that toxicity is related to the hydrophobicity and thus the Kow of the specific AE homologue .
3. APPLICABILITY DOMAIN
- Descriptor domain: log kow of 5.3 (predicted using Episuite which is based on Leo and Hansch calculation). It is difficult to get accurate results for experimental determinations of Log Pow of surfactants.
- Structural and mechanistic domains: C11-15AE3
- Similarity with analogues in the training set: the log Kow is in the middle of the training set range and structurally it has bigger distribution of the alkyl chain length with a shorter ethoxylated chain.
- Other considerations (as appropriate):Although toxicity was found to decrease with increasing ethylene oxide chain length, secondary attachments of the alkyl group were reported to be less chronically toxic than linear primary AE.
4. ADEQUACY OF THE RESULT
Due to the insufficient number of data points (three early life stage studies), this cannot be considered a reliable QSAR, but it is given for completeness. However the fish is not the most sensitive of the aquatic organisms to AE. - Principles of method if other than guideline:
- - Principle of test: A new QSAR technique for complex substances, which interprets the mixture toxicity with regard to the‘‘ethoxymers’’ distribution (i.e., the individual AE components) rather than the average structure, was developed (Boeije et al, 2006) using the Log Kow.
- Short description of test conditions: 30-day study
- Parameters analysed / observed: NOEC for chronic Fish (survival) - Duration:
- 32 d
- Dose descriptor:
- EC10
- Effect conc.:
- 0.87 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: egg survival
- Remarks on result:
- other: Pimephales promelas
- Remarks:
- QSAR
- Validity criteria fulfilled:
- yes
- Endpoint:
- long-term toxicity to fish, other
- Type of information:
- other: Review of the ecotoxicology profile similarity between softanol 30 and the alcohol ethoxylates described in several publications and assessment of data from available studies to waive the execution of a long term fish study
- Adequacy of study:
- weight of evidence
- Reliability:
- other: Review of data extracted from publications
- Principles of method if other than guideline:
- This is a review of the ecotoxicology profile between softanol 30 and the alcohol ethoxylates described in several publications. The aim is to assess the similarity of the data from available studies with softanol 30 and other alcohol ethoxylates in order to confirm the applicability of the chronic fish QSAR and waive the execution of a long term toxicity study to fish with softanol 30.
The notifier has performed acute toxicity studies to aquatic organisms with softanol. Acute and long-term toxicity laboratory and field studies to fish toxicity studies are available with other alcohol ethoxylates. - Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.18 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: Fathead minnow larvae survival
- Remarks on result:
- other: C14-15AE7
- Remarks:
- in lab study
- Duration:
- 12 mo
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.32 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: Fathead minnow survival and reproduction lab study
- Remarks on result:
- other: C12-15AE6,5
- Remarks:
- in lab studies
- Duration:
- 10 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.16 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: Fathead minnow survival
- Remarks on result:
- other: C14-15AE7
- Remarks:
- in lab studies
- Duration:
- 10 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 0.46 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: Fathead minnow survival
- Remarks on result:
- other: C14-15AE7
- Remarks:
- in lab studies
- Duration:
- 30 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.28 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- other: Fathead minnow survival
- Remarks on result:
- other: C14-15AE7
- Remarks:
- in outdoor stream mesocosms
Referenceopen allclose all
Description of key information
Chronic fish endpoint was calculated using a Chronic QSAR algorythm developed by Boeije et al (2006)
Fish survival EC10 = 10-0.280 log Kow+1.90= 2.61 μmol/L (0.87 mg/L)
For softanol 30, the log Kow is estimated to be 5.3; molar-to-mass conversions were carried out using its Mw of 334.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.87 mg/L
Additional information
A new long-term toxicity study to fish with softanol 30 is waived due to availability of data on other ethoxylated alcohols and a chronic QSAR developed for alcohol ethoxylates by Boeije et al (2006). This QSAR was used to calculate the EC10 for softanol 30.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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