Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 611-591-5 | CAS number: 57903-73-8
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no studies available for the determination of toxicokinetics or dermal absorption.
Pentaerythritol, oligomeric reaction products with 1-chloro-2,3-epoxypropane, reaction products with acrylic acid is a slightly yellow liquid with a molecular weight of 790-910g/mol, and a low vapour pressurebelow 0.01 hPa. In agreement with its logPow of >3 the water solubility is relatively low (app 700mg/l). The molecular weight below 1000g/mol favours absorption after oral exposure, but might limit dermal or inhalation uptake. But since sensitization was observed and hydrolysis of the substance is expected to occur on the skin dermal absorption cannot be excluded. Water solubility between 100-10,000mg/l and a logPoW just above 4 will also rather favour oral and dermal uptake. Uptake via inhalation is expected to be low due to the low vapour pressure. In an acute dermal and oral toxicity study, no signs of systemic toxicity were observed, either because of limited uptake or the relative non-toxicity of the test substance, as was also observed for the structurally related compound.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
