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EC number: 939-717-7 | CAS number: 1474044-79-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study generally follows accepted procedures (Draize method) with an appropriate number of animals and dosing regime.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSLA. CFR Title 21, para. 191.11.
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- NASUL 729
- IUPAC Name:
- NASUL 729
- Test material form:
- liquid: viscous
- Details on test material:
- 50% Calcium salt of Dinonylnaphthalene Sulfonic Acid (DNNSA)
50% light paraffinic and naphthenic petroleum distillates
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- Fivetenths of a milliliter (0.5 ml) of test material was placed under each patch. The patches were
secured with tape and covered with a plastic trunk band to pjevent evaporation. - Duration of treatment / exposure:
- The rabbits were immobil ized in head stocks for 24 hours at which time the patches were
removed and the rabbits returned to their cages. - Observation period:
- Skin lesions were evaluated at 24 and 72 hours
- Number of animals:
- 6
- Details on study design:
- The rabbits were prepared by cl ipping the skin of the trunk free of hair. Epidermal abrasions were made over a 2-3 cm2
area on each rabbit. Two, 2.5 cm2 gauze patches were placed on each rabbit. One second patch over the abraded skin. Five-tenths
of a mill il iter of test material was placed under each patch. The patches were secured with tape and covered with a plastic
trunk band to pjevent evaporation. The rabbits were immobil ized in head stocks for 24 hours at which time the patches were
removed and the rabbits returned to their cages.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- average of 6
- Time point:
- other: 72
- Score:
- ca. 8.99
- Reversibility:
- no data
- Remarks on result:
- other: see attached tables for details
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 0.66
- Reversibility:
- no data
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72
- Score:
- ca. 2.41
- Reversibility:
- no data
- Irritant / corrosive response data:
- See table.
- Other effects:
- No clinical symptoms reported.
Any other information on results incl. tables
Evaluation of Skin Reactions and Scoring Criteria
Erythema and Eschar Formation |
Exposure Time hours |
Average Exposure Unit Value |
Intact Skin |
24 |
1.83 |
|
72 |
2.66 |
Abraded Skin |
24 |
2.17 |
|
72 |
2.33 |
Edema Formation |
Subtotal |
8.99 |
Intact Skin |
24 |
0 |
|
72 |
0.33 |
Abraded Skin |
24 |
0 |
|
72 |
0.33 |
|
Subtotal |
0.66 |
|
Total |
9.65 |
|
Primary Irritation Score (Index)
|
2.41 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- NASUL 729 was determined to be a moderate skin irritant.
- Executive summary:
NASUL 729 was evaluated for skin irritation following U.S. Federal Hazardous Substances Labeling Act (FHSLA) procedures. Rabbits were prepared by clipping the skin of the trunk free of hair. Epidermal abrasions were made over a 2-3 cm2area on each rabbit. Two, 2.5 cm2gauze patches were placed on each rabbit. One patch on the intact skin and a second patch over the abraded skin. Five-tenths of a milliliter (0.5) of test material was placed under each patch. The patches were secured with tape and covered with a plastic trunk band to prevent evaporation. The rabbits were immobilized in head stocks for 24 hours at which time the patches were removed and the rabbits returned to their cages. Skin lesions were evaluated at 24 and 72 hours and scored. NASUL 729 had primary irritation score of 2.41 indicating moderate skin irritation.
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