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EC number: 298-265-2 | CAS number: 93783-70-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Studies on read across substances showed:
- no skin irritation
- serious eye damage/irreversible adverse effects
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
No experimental data on target substance was available, thus available data on different salifications, i.e. Similar Substance 01 and 02, was used as read across. Details on the read across approach are available in section 13.
The skin irritation potential was examined in 2 tests on Similar Substance 01 (1989 and 1984) and one test on Similar Substance 02 (1984).
In all studies, test substance was applied for 4 hours in a semiocclusive manner to the skin of 3 rabbits. Animals were observed for up to day 7 upon exposure; oedema and erythema scores were recorded 24 h, 48 h, 72 h and 7 d after patch removal. In both the supporting studies (1984), erythema could not be assessed due to blue colour of skin.
No signs of local irritation were reported and skin of 3/3 animals gave the following mean reaction scores (24, 48 and 72 h): erythema score = 0 (when available) and oedema score = 0.
The eye irritation potential of test substance was examined in 3 tests (1989, 1984, 1984), using the same test materials as in skin irritation studies.
In the key study (1989), Similar Substance 01 was applied to the eye of one rabbit for 24 h, then the eye was rinsed. After an observation period of 72 h, effects were considered as irreversible and the animal was killed. Mean irritation indices (at 24, 48 and 72 h) for 1/1 animal were as follows: cornea = 2.7, iris = 4 and conjunctivae = 3.
In a supporting study (1984), 3 rabbits were exposed to Similar Substance 01 for 24 h, then the eye was rinsed. Then, eye reactions were scored at 24 h, 48 h, 72 h, 7 d, 14 d and 21 d after exposure. The mean irritation indices (at 24, 48 and 72 h) for 3/3 animals were the following: cornea ≥ 3, iris = 1 and conjuctivae = 3 and these effects were not reversible by 21 days.
In another supporting study (1984), 3 rabbits were exposed to Similar Substance 02 for 24 h, then the eye was rinsed. Then, eye reactions were scored at 24 h, 48 h, 72 h, 7 d, 14 d and 21 d after exposure. The mean irritation indices (at 24, 48 and 72 h) for 3/3 animals were the following: cornea = 2, iris = 1.3 and conjuctivae = 3 and these effects were not reversible by 21 days.
Despite different composition of test material in 3 tests, results were coherent and in agreement. As reactions recorded in all animals were not reversible by 21 days, test substance was considered as able to cause serious eye damage.
Justification for classification or non-classification
Classification criteria for effects on skin and eye upon topical application are reported in the CLP Regulation (EC 1272/2008). A decision on classification was based on available studies reporting:
- no signs of skin irritation, thus mean scores below the threshold for classification, i.e. 2.3
- signs of irreversible eye damage
Therefore, classification as substance that causes serious eye damage, i.e. H318, was applied.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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