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Diss Factsheets
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EC number: 202-182-9 | CAS number: 92-72-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study carried out prior to OECD and GLP GL. Some relevant criteria (dosing, observation times, assessment) similar to OECD GL
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US FDA Title 16, Section 1500.41
- GLP compliance:
- no
- Remarks:
- pre-guideline study
Test material
- Reference substance name:
- 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide
- EC Number:
- 202-182-9
- EC Name:
- 5'-chloro-3-hydroxy-2',4'-dimethoxy-2-naphthanilide
- Cas Number:
- 92-72-8
- Molecular formula:
- C19H16ClNO4
- IUPAC Name:
- N-(5-chloro-2,4-dimethoxyphenyl)-3-hydroxy-2-naphthamide
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Hoechst AG, own breeding strain
- Strain: SPF-Albino-Himalayan, Hoe HIMK(SPFWiga)
- Housing: single cage
- Diet: ERKA 8300, ad libitum
- Water: tap water, ad libitum
Test system
- Type of coverage:
- other: patch covered by a neutral, impermeable PVC film + elastic bandage
- Preparation of test site:
- other: clipped intact and clipped scarified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 6
- Details on study design:
- 0.5 g of the test substance placed on a square gauze patch, 2,5 x 2,5 cm of size was applied on a clipped/intact and clipped/scarified skin of the albino rabbit. The patches were fixed by an adhesive tape and additionally covered by a neutral, impermeable PVC film. The entire trunk of the animal is then wrapped with an elastic bandage. After 24 hours of exposure the patches are removed and the resulting reactions are evaluated. Readings are again made after 48 h and 72 h.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: mean of 24, 48, 72 h after beginning of treatment
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant since no effect occured
- Remarks on result:
- other: no effect on any single animal
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- of all tested animals
- Time point:
- other: mean of 24, 48, 72 h after beginning of treatment
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not relevant since no effect occured
- Remarks on result:
- other: no effect on any single animal
- Other effects:
- no other effects reported
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Classification acc. to (EC) 1272/2008: not irritating
This conclusion is legitimate even though the applied testing regime differs from today's standard methods. Since the test conditions were more stringent than required by OECD TG 404 (i.e. 24 h treatment, occlusive coverage, and scarified skin instead of 4 h treatment, semi-occlusive coverage, and intact skin) the test results are considered adequate to fulfill the endpoint requirements. - Executive summary:
The test material was tested for skin irritancy according to FDA guideline. Both intact and scarified skin sites of six rabbits were exposed to 0.5 g test substance for 24 h under occlusive conditions and the skin responses were examined at 24, 48, and 72 h after beginning of treatment. Mean values of the 24, 48 and 72 h readings were calculated for each animal. No effects were observed on each rabbit. The same results were obtained for scarified skin. Based on these findings the test material was judged not to be irritating to skin.
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