(S)-p-mentha-1,8-diene

GHS

General Information

Implementation:

EU

Remarks:

Self-classification.

Signal word "Danger" and hazard statement "H304: May be fatal if swallowed and enters airways" are required according to the data available, being the substance classified for Aspiration Hazard Category 1 according to CLP Regulation (EC) nº 1272/2008.

In two GLP studies performed with d-limonene according to OECD guideline 404, the maximum score obtained for erythema and edema was 2. According to CLP Regulation (EC) n° 1272/2008, the major criterion for the irritant category is that at least 2 of 3 tested animals have a mean score of ≥ 2.3; therefore, l-limonene (by read-across) should not be classified for skin irritation according to CLP Regulation (EC) n° 1272/2008. l-limonene is currently classified for skin irritation "H315: Causes skin irritation." according to Annex VI of CLP Regulation (EC) n° 1272/2008. This classification is not supported by the data submitted in the registration dossier. The recommendation is made to declassify l-limonene for skin irritation.

The substance is classified for Skin sensitization Category 1 according to Annex VI of CLP Regulation (EC) nº 1272/2008. Based on available experimental (OECD 429) data where an EC3 of 68.3% was obtained, the substance should be classified as Skin sensitizer Category 1B, since the EC3 value is higher than 2%.

The substance is classified as Aquatic Acute Cat. 1 based on the acute toxicity data (EC50 < 1 mg/L). This classification is in accordance to the harmonized classification (Annex VI of CLP Regulation (EC) n° 1272/2008). However, the available chronic toxicity data lead to a classification in Aquatic Chronic 3 (NOEC between 0.1 and 1 mg/L, ready biodegradable substance) which is not in accordance with the current harmonized classification in the Annex VI of CLP Regulation (EC) n° 1272/2008 (i.e. Aquatic Chronic 1). The Hazard statement "H410: Very toxic to aquatic life with long lasting effects" should be replaced by "H412: Harmful to aquatic life with long lasting effects".

Related composition

Related composition:

l-limonene

l-limonene

Classification

Physical hazards

Explosives

Reason for no classification:

data conclusive but not sufficient for classification

Flammable gases and chemically unstable gases

Reason for no classification:

data conclusive but not sufficient for classification

Aerosols

Reason for no classification:

data conclusive but not sufficient for classification

Reason for no classification:

hazard class not assessed

Oxidising gases

Reason for no classification:

data conclusive but not sufficient for classification

Gases under pressure

Reason for no classification:

data conclusive but not sufficient for classification

Flammable liquids

Hazard category:

Flam. Liquid 3

Hazard statement:

H226: Flammable liquid and vapour.

Flammable solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-reactive substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric liquids

Reason for no classification:

data conclusive but not sufficient for classification

Pyrophoric solids

Reason for no classification:

data conclusive but not sufficient for classification

Self-heating substances and mixtures

Reason for no classification:

data conclusive but not sufficient for classification

Substances and mixtures which in contact with water emit flammable gases

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising liquids

Reason for no classification:

data conclusive but not sufficient for classification

Oxidising solids

Reason for no classification:

data conclusive but not sufficient for classification

Organic peroxides

Reason for no classification:

data conclusive but not sufficient for classification

Corrosive to metals

Reason for no classification:

data conclusive but not sufficient for classification

Desensitized explosives

Reason for no classification:

data lacking

Health hazards

Acute toxicity - oral

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - dermal

Reason for no classification:

data conclusive but not sufficient for classification

Acute toxicity - inhalation

Reason for no classification:

data conclusive but not sufficient for classification

Skin corrosion / irritation

Reason for no classification:

data conclusive but not sufficient for classification

Serious eye damage / eye irritation

Reason for no classification:

data conclusive but not sufficient for classification

Respiratory sensitisation

Reason for no classification:

data lacking

Skin sensitisation

Hazard category:

Skin Sens. 1B

Hazard statement:

H317: May cause an allergic skin reaction.

Aspiration hazard

Hazard category:

Asp. Tox. 1

Hazard statement:

H304: May be fatal if swallowed and enters airways.

Reproductive toxicity

Reason for no classification:

data conclusive but not sufficient for classification

Effects on or via lactation

Reason for no classification:

data lacking

Germ cell mutagenicity

Reason for no classification:

data conclusive but not sufficient for classification

Carcinogenicity

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - single (STOT-SE)

Reason for no classification:

data conclusive but not sufficient for classification

1. Specific target organ toxicity - repeated (STOT-RE)

Reason for no classification:

data conclusive but not sufficient for classification

Environmental hazards

Hazardous to the aquatic environment (acute / short-term)

Hazard category:

Aquatic Acute 1

Hazard statement:

H400: Very toxic to aquatic life.

Hazardous to the aquatic environment (long-term)

Hazard category:

Aquatic Chronic 3

Hazard statement:

H412: Harmful to aquatic life with long lasting effects.

M-Factor chronic:

1

Hazardous to the ozone layer

Reason for no classification:

data conclusive but not sufficient for classification

Labelling

Signal word:

Danger

Hazard pictogram

GHS02: flame

GHS07: exclamation mark

GHS08: health hazard

GHS09: environment

Hazard statements

H226: Flammable liquid and vapour.

H317: May cause an allergic skin reaction.

H304: May be fatal if swallowed and enters airways.

H410: Very toxic to aquatic life with long lasting effects.

Precautionary statements

P273: Avoid release to the environment.

P280: Wear protective gloves/protective clothing/eye protection/face protection/hearing protection/...

P301+P310: IF SWALLOWED: Immediately call a POISON CENTER/doctor/…

P331: Do NOT induce vomiting.

P302+P352: IF ON SKIN: Wash with plenty of water/…

P333+P313: If skin irritation or rash occurs: Get medical advice/attention.

P501: Dispose of contents/container to ...

Notes

Note C