Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 905-013-3 | CAS number: -
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP and pre-OECD test guideline study
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Studies in detoxication: The biological reduction of l-menthone to d-neomenthol and of d-isomenthone to d-isomenthol in the rabbit. The conjugation of d-neomenthol with glucuronic acid.
- Author:
- Williams RT
- Year:
- 1 940
- Bibliographic source:
- PMID:16747209 Biochem J 34(5):690-7
- Reference Type:
- review article or handbook
- Title:
- Detoxication mechanisms. The Metabolism and Detoxication of Drugs, Toxic Substances and Other Organic Compounds: The Metabolism of Terpenes and Camphors
- Author:
- Williams RT
- Year:
- 1 959
- Bibliographic source:
- London, U.K. (Chapman & Hall). 526 p
Materials and methods
- Objective of study:
- metabolism
Test guideline
- Qualifier:
- no guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- d-isomenthone
- IUPAC Name:
- d-isomenthone
- Details on test material:
- - Name of test material (as cited in study report): d-isomenthone
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: no data
- Individual metabolism cages: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- PREPARATION OF DOSING SOLUTIONS: 3 g of d-isomenthone
HOMOGENEITY AND STABILITY OF TEST MATERIAL: no data - Duration and frequency of treatment / exposure:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 g/animal
- No. of animals per sex per dose / concentration:
- 8
- Details on study design:
- no data
- Details on dosing and sampling:
- METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled: urine
- Time and frequency of sampling: during 2 days
- From how many animals: no data
- Method type(s) for identification: optical rotation, melting point, reftactive index
- Limits of detection and quantification: no data
TREATMENT FOR CLEAVAGE OF CONJUGATES: hydrolysed by dilute acid
Results and discussion
Main ADME results
- Type:
- metabolism
- Results:
- d-Isomenthone is reduced in the rabbit, d-isomenthol (isolated as the glucuronide) being identified as a reduction product.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- At least part of the d-isomenthone molecule is reduced in the rabbit to menthanols one of which is d-isomenthol.
Applicant's summary and conclusion
- Conclusions:
- d-Isomenthone is reduced in the rabbit to d-isomenthol.
- Executive summary:
d-Isomenthone is reduced in the rabbit and d-isomenthol was identified as a reduction product.
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