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EC number: 262-108-6 | CAS number: 60209-82-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16 Nov 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions (no GLP, no analytical purity)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Version / remarks:
- adopted 1984
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.11 (Biodegradation: Activated Sludge Respiration Inhibition Test)
- GLP compliance:
- no
- Remarks:
- no GLP statement
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source of inoculum: Activated sludge was obtained on 14 Nov 2011 from the sewage treatment plant at Maxéville, France, which treats predominantly domestic sewage (98%).
- Treatment of sludge: On the day of collection, the sludge was washed three times with dechlorinated water (centrifugation for 10 min at 1100 x g followed by resuspension).
- Method of cultivation: The sludge was kept under constant aeration and was fed with synthetic sewage every 24 h.
- Initial suspended matter concentration: 4.0 g/L ± 10%
- Concentration of suspended matter in test flasks: 1.6 g/L ± 10% - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20 ± 2 °C
- Nominal and measured concentrations:
- Nominal: control, 10, 31.6, 100, 316 and 1000 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: wide-mouth flasks
- Material, size, fill volume: glass, 1 L flasks for incubation (750 mL of culture), 550 mL flasks for oxygen measurement (550 mL of culture)
- Aeration: yes, aeration rate of 0.5 - 1 L/min
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Dechlorinated tap water was used in the test.
EFFECT PARAMETERS MEASURED:
- After 3 h of incubation, the respiration rate was measured during 10 min.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 3.16 - Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC10
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Details on results:
- - Inhibition of respiration rates: Inhibition was 8, 15, -36, -26 and -12% at 10, 31.6, 100, 316 and 1000 mg/L, respectively (first measurement). Inhibition was -12, -46, -31, -33 and -10% at 10, 31.6, 100, 316 and 1000 mg/L, respectively (second measurement)
- All validity criteria were fulfilled. - Results with reference substance (positive control):
- - Results with reference substance valid? yes
- Relevant effect levels: EC50 (3 h) = 15.5 mg/L (accepted range: 5 to 30 mg/L)
Reference
Description of key information
NOEC (3 h): ≥ 1000 mg/L (OECD 209)
Key value for chemical safety assessment
Additional information
One study investigating the toxicity of isodecyl pivalate (CAS 60209-82-7) to activated sludge microorganisms is available. The study was conducted according to OECD 209 (adopted 1984) under non-GLP conditions. Five concentrations up to 1000 mg/L (nominal) were tested. No inhibition of respiration of activated sludge microorganisms was observed after 3 h, resulting in a NOEC (3 h) ≥ 1000 mg/L and an EC10 (3 h) > 1000 mg/L.
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