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EC number: 200-441-0 | CAS number: 59-67-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Nicotinic acid
- EC Number:
- 200-441-0
- EC Name:
- Nicotinic acid
- Cas Number:
- 59-67-6
- Molecular formula:
- C6H5NO2
- IUPAC Name:
- nicotinic acid
- Test material form:
- solid: crystalline
- Details on test material:
- - Name of test material: Nicotinic acid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Mean body weight: 104.1 +/- 1.9 g (males) and 95.8 +/- 1.1 g (females)
- Housed in groups of five in screen-bottomed stainless steel cages, in a well-ventilated room, maintained at 23 +/1 1 degree C
- Stock diet and tap water were provided.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- as 33% suspension in 0.5% aqueous solution of carboxymethyl cellulose
- Details on oral exposure:
- - Formulation: 33 % (w/v) aqueous solution, by oral gavage
- Volumes: 10.0 mL/kg to 20.7 mL/kg. - Doses:
- 3.30, 3.96, 4.75, 5.71 and 6.83 g/kg body weight.
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- The test substance was given by gavage as a 33 % (w/v) suspension in a 0.5 % aqueous solution of carboxy methyl cellulose (CMC) to groups of ten males and ten females in single doses of 10.0, 12.0, 14.4, 17.3 or 20.7 ml/kg body weight. After treatment, the rats received stock diet and tap water ad libitum. They were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors.
- Statistics:
- The LD50 values were calculated according to the method of Weil (Biometrics 8 (1952): 249-263) for males and females separately, both after 24 hours and after 14 days.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 5 210 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 740 - < 5 730
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 170 - < 4 860
- Mortality:
- At 24 hours after dosing, 1 male and 2 females in the 2.88 g/kg group had expired, as did 4 each (male and female) in the 3.44 g/kg group, and 5 males and 7 females from the 4.16 g/kg dose group. After 14 days, no additional animals died in the 2.88 g/kg group. However, the total number of deaths at 14 days in the two higher groups were: 5 males and 4 females in the 3.44 g/kg group and 8 males and 8 females in the 4.16 g/kg group.
- Clinical signs:
- other: Within one hour after dosing, the rats showed sluggishness and signs of ataxia. Later on coma was frequently observed. Most of the deaths occurred between 1 and 20 hours after dosing. Three males and three females, however, succumbed between day 2 and 4
- Gross pathology:
- Macroscopic examination of the survivors at autopsy did not reveal any treatment—related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An acute oral toxicity test, similar to OECD 401 guideline, was undertaken on nicotinic acid. Male and female Wistar rats were given solutions of the test substance suspended in CMC at concentrations ranging from 3.30-6.83 g/kg bw, and observed for 14 days. The LD50 was found to be 5.21 g/kg bw in males and 4.50 g/kg bw in females.
- Executive summary:
A study similar or equivalent to OECD Guideline 401 (Acute toxicity oral) was carried out. Male and female Wistar rats were given solutions of the test substance suspended in CMC at concentrations ranging from 3.30-6.83 g/kg bw, and observed for 14 days. The LD50 was found to be 5210 mg/kg bw in males and 4500 mg/kg bw in females. The test item was considered to be practically non-toxic.
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