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EC number: 206-851-6 | CAS number: 383-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 1983-03-03 to 1983-03-28
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No GLP compliance. Study performed similarly to the OECD guideline No. 402 with some restrictions: no data on the percentage of the application surface, the animals are not individually housed, an occlusive dressing is used.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- : no data on the percentage of the application surface, the animals are not individually housed, an occlusive dressing is used.
- Principles of method if other than guideline:
- Not applicable.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Ethyl trifluoroacetate
- EC Number:
- 206-851-6
- EC Name:
- Ethyl trifluoroacetate
- Cas Number:
- 383-63-1
- Molecular formula:
- C4H5F3O2
- IUPAC Name:
- ethyl 2,2,2-trifluoroacetate
- Details on test material:
- - Name of test material (as cited in study report): Trifluoroacetate d'ethyle
- Physical state: clear liquid
- Stability under test conditions: assume to be stable (sponsor responsibility)
- Storage condition of test material: no data
- Other: density: 1.19
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: centre d'élevage d'IFFA CREDO (69210 St-Germain sur l'Arbresle, France)
- Age at study initiation: 6-7 weeks
- Weight at study initiation: males: 190-200 g - females: 150-160 g
- Fasting period before study: not required
- Housing: per group of 2 or 5 animals in plastic cages (37.5 x 17 x 15 cm) with sawdust litter
- Diet (e.g. ad libitum): Souriffarat diet, ad libitum
- Water (e.g. ad libitum): tap water, ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1.5 °C
- Humidity (%): 55 +/- 15%
- Air changes (per hr): 10
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To: no data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- the test item was applied as supplied by the sponsor
- Details on dermal exposure:
- TEST SITE
- Area of exposure: lateral dorsal area
- % coverage: no data
- Type of wrap if used: the test item is spread on the skin and then the application's area is covered with silver foil and surgical tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): none
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.85 or 1.69 mL/kg
- Concentration (if solution): not applicable, the test item is applied undiluted on the skin
- Constant volume or concentration used: no
- For solids, paste formed: yes/no
VEHICLE
not applicable, the test item is applied undiluted on the skin. - Duration of exposure:
- 24 hours after the application of the test item on the skin, the dressing was removed. The skin was not washed.
- Doses:
- Preliminary test: 1011 and 2011 mg/kg bw
Main test: 0 and 2011 mg/kg bw
see details in Table 7.2.3/1 - No. of animals per sex per dose:
- Preminary test: 2
Main test: 5 - Control animals:
- yes, concurrent no treatment
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: clinical signs: at the removal of the dressing, 1h, 2h and 6h after the removal of the dressing and then daily until the end of the test. Weighing: at the removal of the dressing and then at day 1, 2, 4, 7 and 14 after the removal.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macroscopic observations - Statistics:
- no data
Results and discussion
- Preliminary study:
- No mortality occured at any test doses (1011 and 2011 mg/kg bw).
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 011 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured.
- Clinical signs:
- other: No effects were observed.
- Gross pathology:
- No effects were observed.
- Other findings:
- none
Any other information on results incl. tables
No other information.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, since the LD50 is higher than 2011 mg/kg bw, Ethyl Trifluoroacetate is not classified for acute dermal toxicity according to the Annex I of the Regulation (EC) 1272/2008 (CLP) and the Annex VI of the Directive 67/548/EEC.
- Executive summary:
In an acute dermal toxicity study performed similarly to the OECD guideline No. 402, groups of male and female Sprague-Dawley rats (2 for the preliminary test and 5 animals for the main test/sex/dose) were treated with a single dermal dose of undiluted Ethyl trifluoroacetate (97.3 %). In the preliminary test, 2 doses were tested: 1011 and 2011 mg/kg bw. As no mortality occurred, the highest dose of 2011 mg/kg bw was chosen for the main test. A group consisted in 2 males and 2 females, received no treatment, and served as control group during the main test. The test item was applied on the lateral dorsal area of rats and then the application site was covered with an occlusive dressing (silver foil and surgical tape). 24 hrs after the application of the test item, the dressing was removed and the application site was not washed.
Clinical signs and mortality were checked at the removal of the dressing, then 1h, 2h and 6h after the removal, and then daily until the end of the test (14 days). The body weight gain was measured at the removal of the dressing and then at day 1, 2, 4, 7 and 14 after the removal. 14 days after the end of application, the animals were killed and necropsied for macroscopic observations.
No mortalities occurred; neither clinical signs nor effects on body weight gain were observed. Macroscopic examination of the main organs of the animals revealed no apparent abnormalities.
Therefore the LD50 was determined to be higher than 2011 mg/kg bw.
Under the test conditions, Ethyl Trifluoroacetate is not classified for acute dermal toxicity according to the Annex I of the Regulation (EC) 1272/2008 (CLP) and the Annex VI of the Directive 67/548/EEC.
This study is considered as acceptable and satisfies the requirement for acute dermal toxicity endpoint.
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