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EC number: 212-058-6 | CAS number: 757-86-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 01-10-1992 to 28-10-1992
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Methyl [(dimethoxyphosphinothioyl)thio]acetate
- EC Number:
- 212-058-6
- EC Name:
- Methyl [(dimethoxyphosphinothioyl)thio]acetate
- Cas Number:
- 757-86-8
- Molecular formula:
- C5H11O4PS2
- IUPAC Name:
- methyl 2-{[dimethoxy(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}acetate
- Details on test material:
- - Name of test material (as cited in study report): MPEM
- Substance type: Intermediate
- Physical state: Liquid
- Purity test date:
- Lot/batch No.: 20825
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Møllegaard Breeding Centre Ltd, Ejby, DK-4623 Ll. Skensved, Denmark
- Age at study initiation: 6-7 weeks
- Weight at study initiation: 134-164 g
- Fasting period before study: -
- Housing: Macrolone cages type III, 2 or 3 to a cage, males and females separated. The bedding was pinewood sawdust "Linocel Granulat" from Compagny Altromin GmbH D-4937 Lage, Lippe, Germany
- Diet : "Altromin 1314" from Compagny Altromin GmbH D-4937 Lage, Lippe, Germany
- Water : ad libitum, acidified with hydrochloric acid to pH 2,5.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21, ± 3
- Humidity (%):55, ± 15
- Air changes (per hr): 10 times
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- peanut oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:-
- Amount of vehicle (if gavage): 10 ml/kg b.w.
- Justification for choice of vehicle:
- Lot/batch no. (if required): 20825
- Purity:-
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: range finding showed LD50 over 2000 mg/kg b.w., therefore this was chosen chosen for only one group - Doses:
- 2000 mg/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observations: 3 times the first day, thereafter daily
Weighing: daily
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other:
Results and discussion
- Preliminary study:
- It was expected that the LD50 would exceed 2 g test material/kg body weight. Therefore the study was initiated with one group consisting of 5 males and 5 females, which all were adnistered 2000 mg methyl [(dimethoxyphosphinothioyl)thio]acetate per kg of body weight.
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- None
- Clinical signs:
- other: Piloerection and pinched abdomen on day of treatment, piloerection day 1-4. from day 5 and onwards no symptoms
- Gross pathology:
- None
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Since no rats died of the treatment, the oral LD50 of methyl [(dimethoxyphosphinothioyl)thio]acetate must exceed 2000 mg/kg body weight.
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